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Tchem
MAP3K5
Mitogen-activated protein kinase kinase kinase 5

Protein Summary
Description
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359015
  • ENSP00000351908
  • ENSG00000197442

Symbol
  • ASK1
  • MAPKKK5
  • MEKK5
  • ASK1
  • MEKK5
  • MAPKKK5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
kinase
1
molecular function
1
PubMedID
0.96
biological term
0.94


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 787.59   (req: < 5)
Gene RIFs: 164   (req: <= 3)
Antibodies: 1449   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 787.59   (req: >= 5)
Gene RIFs: 164   (req: > 3)
Antibodies: 1449   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 54
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
72.3
neutrophil count
2
1
2
72.1
monocyte count
1
1
1
68.8
eosinophil count
2
1
2
68.8
high density lipoprotein cholesterol measurement
2
2
2
56
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
72.3
neutrophil count
2
72.1
monocyte count
1
68.8
eosinophil count
2
68.8
high density lipoprotein cholesterol measurement
2
56
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 5
VGNC:10797
463023
Macaque
mitogen-activated protein kinase kinase kinase 5
711382
Mouse
MGI:1346876
26408
Rat
RGD:1306565
365057
Dog
mitogen-activated protein kinase kinase kinase 5
VGNC:42975
476215
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 5
Macaque
mitogen-activated protein kinase kinase kinase 5
Mouse
Rat
Dog
mitogen-activated protein kinase kinase kinase 5
Protein Structure (20 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99683-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 20
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (51)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Oxidative Stress Induced Senescence
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Oxidative Stress Induced Senescence
Gene Ontology Terms (46)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (213)
1 – 10 of 213
TNFSF13B
Tclin
Novelty: 0.00069885
p_int: 1
Score: 0.268
Data Source: BioPlex,STRINGDB
TXN
Tchem
Novelty: 0.00048949
Score: 0.994
Data Source: Reactome,STRINGDB
DAXX
Tbio
Novelty: 0.00348585
Score: 0.994
Data Source: STRINGDB
DAB2IP
Tbio
Novelty: 0.01423445
Score: 0.992
Data Source: STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.988
Data Source: STRINGDB
TRAF2
Tbio
Novelty: 0.00983658
Score: 0.984
Data Source: STRINGDB
FAS
Tbio
Novelty: 0.00043286
Score: 0.979
Data Source: STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.975
Data Source: STRINGDB
TRAF1
Tbio
Novelty: 0.00526776
Score: 0.974
Data Source: STRINGDB
TNF
Tclin
Novelty: 0.00001457
Score: 0.971
Data Source: STRINGDB
Publication Statistics
PubMed Score  787.59

PubMed score by year
PubTator Score  347.38

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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