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Tchem
MAP3K5
Mitogen-activated protein kinase kinase kinase 5

Protein Summary
Description
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359015
  • ENSP00000351908
  • ENSG00000197442

Symbol
  • ASK1
  • MAPKKK5
  • MEKK5
  • ASK1
  • MEKK5
  • MAPKKK5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
kinase
1
molecular function
1
PubMedID
0.96
biological term
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 881.44   (req: < 5)
Gene RIFs: 164   (req: <= 3)
Antibodies: 1449   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 881.44   (req: >= 5)
Gene RIFs: 164   (req: > 3)
Antibodies: 1449   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 127
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0