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Tbio
GPR22
G-protein coupled receptor 22

Protein Summary
Description
Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway (PubMed:18539757). May be involved in ciliogenesis (By similarity). This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304402
  • ENSP00000302676
  • ENSG00000172209
  • ENST00000639742
  • ENSP00000492841
  • ENSG00000283812
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.6
kinase perturbation
0.54
disease perturbation
0.49
cell type or tissue
0.48
small molecule perturbation
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.78   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 270   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.78   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
GPR20
Tdark
Family:  GPCR
Novelty:  0.34435286
Score:  0.931
Data Source:  STRINGDB
DUS4L
Tbio
Family:  Enzyme
Novelty:  0.05943255
Score:  0.808
Data Source:  STRINGDB
LPAR4
Tchem
Family:  GPCR
Novelty:  0.02200758
Score:  0.803
Data Source:  STRINGDB
BCAP29
Tbio
Novelty:  0.09095623
Score:  0.767
Data Source:  STRINGDB
GPR1
Tchem
Family:  GPCR
Novelty:  0.01313419
Score:  0.756
Data Source:  STRINGDB
COG5
Tbio
Novelty:  0.04017657
Score:  0.752
Data Source:  STRINGDB
CCDC174
Tdark
Novelty:  0.37189828
Score:  0.692
Data Source:  STRINGDB
PRKAR2B
Tchem
Family:  Enzyme
Novelty:  0.00456972
Score:  0.691
Data Source:  STRINGDB
DNM1L
Tchem
Novelty:  0.00151314
Score:  0.645
Data Source:  STRINGDB
DNAJB9
Tbio
Novelty:  0.00536296
Score:  0.635
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
9.2
88.3
alkaline phosphatase measurement
2
2
1
9.2
88.3
vitamin D measurement
2
1
2
63.6
vitamin D measurement
2
1
2
63.6
electrocardiography
1
1
2
57.8
Items per page:
1 – 5 of 22
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
9.2
88.3
alkaline phosphatase measurement
1
9.2
88.3
vitamin D measurement
2
63.6
vitamin D measurement
2
63.6
electrocardiography
2
57.8
Find similar targets by:
IDG Resources
Items per page:
10
1 – 10 of 20
Genetic Construct
pcDNA3.1-GGamma13-GFP2
image for pcDNA3.1-GGamma13-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-GGamma9-GFP2
image for pcDNA3.1-GGamma9-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-GGamma8-GFP2
image for pcDNA3.1-GGamma8-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-GGamma1-GFP2
image for pcDNA3.1-GGamma1-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-Beta3
image for pcDNA3.1-Beta3
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-Beta1
image for pcDNA3.1-Beta1
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA5/FRT/TO-GAlpha13-RLuc8
image for pcDNA5/FRT/TO-GAlpha13-RLuc8
Details:
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Genetic Construct
pcDNA5/FRT/TO-GAlpha12-RLuc8
image for pcDNA5/FRT/TO-GAlpha12-RLuc8
Details:
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Genetic Construct
pcDNA5/FRT/TO-GAlpha15-RLuc8
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Details:
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Genetic Construct
pcDNA5/FRT/TO-GAlpha11-RLuc8
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Details:
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Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 22
VGNC:4378
744517
Macaque
G protein-coupled receptor 22
699492
Mouse
MGI:1920260
73010
Rat
RGD:1310848
298944
Dog
G protein-coupled receptor 22
VGNC:41426
607459
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 22
Macaque
G protein-coupled receptor 22
Mouse
Rat
Dog
G protein-coupled receptor 22
Publication Statistics
PubMed Score 7.78
PubMed score by year
PubTator Score 2.68
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title