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Tdark
GPR21
Probable G-protein coupled receptor 21

Protein Summary
Description
Orphan receptor. This gene encodes a member of the G-protein-coupled receptor 1 family. G-protein coupled receptors are membrane proteins which activate signaling cascades as a response to extracellular stress. The encoded protein activates a Gq signal transduction pathway which mobilizes calcium. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373642
  • ENSP00000362746
  • ENSG00000188394
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.67
kinase perturbation
0.6
cell line
0.57
small molecule perturbation
0.54
tissue sample
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.04   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.04   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
MARCH6
Tbio
Family:  Enzyme
Novelty:  0.01818691
p_int:  0.999998498
p_ni:  0.000001054
p_wrong:  4.48e-7
Data Source:  BioPlex
ERMP1
Tbio
Family:  Enzyme
Novelty:  0.16736317
p_int:  0.999997483
p_ni:  0.000002516
Data Source:  BioPlex
OTUD6A
Tbio
Novelty:  0.52996035
p_int:  0.999986422
p_wrong:  0.000013578
Score:  0.188
Data Source:  BioPlex,STRINGDB
S1PR5
Tclin
Family:  GPCR
Novelty:  0.01032055
p_int:  0.999774091
p_ni:  0.000067144
p_wrong:  0.000158765
Data Source:  BioPlex
FZD3
Tbio
Family:  GPCR
Novelty:  0.00964507
p_int:  0.999513608
p_ni:  0.000398671
p_wrong:  0.000087721
Data Source:  BioPlex
SIDT2
Tbio
Novelty:  0.07560652
p_int:  0.999311733
p_ni:  0.000687992
p_wrong:  2.75e-7
Data Source:  BioPlex
ZDHHC5
Tbio
Family:  Enzyme
Novelty:  0.05205767
p_int:  0.999216953
p_ni:  0.000761759
p_wrong:  0.000021288
Score:  0.166
Data Source:  BioPlex,STRINGDB
SLC6A6
Tbio
Family:  Transporter
Novelty:  0.00333868
p_int:  0.998041375
p_ni:  0.000296961
p_wrong:  0.001661664
Score:  0.162
Data Source:  BioPlex,STRINGDB
SLC15A4
Tbio
Family:  Transporter
Novelty:  0.01325014
p_int:  0.997806742
p_ni:  0.002164641
p_wrong:  0.000028617
Data Source:  BioPlex
SLC47A1
Tchem
Family:  Transporter
Novelty:  0.00535064
p_int:  0.996784469
p_ni:  0.003214968
p_wrong:  5.63e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
3
3
3
79.3
vitamin D measurement
2
2
2
45.6
mathematical ability
2
1
2
24.5
sex hormone-binding globulin measurement
2
1
2
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
3
79.3
vitamin D measurement
2
45.6
mathematical ability
2
24.5
sex hormone-binding globulin measurement
2
13.5
Find similar targets by:
IDG Resources
Genetic Construct
GPR21-Tango
image for GPR21-Tango
Details:
  • Vector:  addgene66345
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR21-Tango
Order Genetic Construct from:
Orthologs
No orthologs found
Publication Statistics
PubMed Score 1.04
PubMed score by year
PubTator Score 1.38
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title