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Tdark
CGRRF1
Cell growth regulator with RING finger domain protein 1

Protein Summary
Description
Able to inhibit growth in several cell lines.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216420
  • ENSP00000216420
  • ENSG00000100532

Symbol
  • CGR19
  • RNF197
  • CGR19
  • RNF197
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.76
histone modification site profile
0.7
transcription factor binding site profile
0.68
tissue sample
0.59
gene perturbation
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.1   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.1   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (54)
1 – 10 of 54
RXFP1
Tchem
Family: GPCR
Novelty: 0.00590091
p_int: 0.999793277
p_ni: 0.000206621
p_wrong: 1.02e-7
Data Source: BioPlex
COLEC12
Tbio
Novelty: 0.00845079
p_int: 0.999037532
p_ni: 0.000962468
Data Source: BioPlex
FOXD2
Tbio
Family: TF
Novelty: 0.13855012
p_int: 0.998639059
p_ni: 0.000005144
p_wrong: 0.001355798
Score: 0.227
Data Source: BioPlex,STRINGDB
KIDINS220
Tbio
Family: Enzyme
Novelty: 0.00070004
p_int: 0.998384229
p_ni: 0.001615771
Score: 0.154
Data Source: BioPlex,STRINGDB
PCDHAC2
Tdark
Novelty: 0.41763341
p_int: 0.996611727
p_ni: 0.003384233
p_wrong: 0.00000404
Data Source: BioPlex
HFE
Tbio
Novelty: 0.00040976
p_int: 0.99652471
p_ni: 0.003445342
p_wrong: 0.000029948
Data Source: BioPlex
BTNL3
Tdark
Novelty: 0.44444444
p_int: 0.996260587
p_ni: 0.003641378
p_wrong: 0.000098034
Data Source: BioPlex
MPPE1
Tbio
Family: Enzyme
Novelty: 0.25531915
p_int: 0.984145079
p_ni: 0.002123521
p_wrong: 0.0137314
Data Source: BioPlex
ATP2A3
Tbio
Family: Transporter
Novelty: 0.01101086
p_int: 0.984143845
p_ni: 0.015856155
Score: 0.156
Data Source: BioPlex,STRINGDB
NKAIN1
Tdark
Family: Enzyme
Novelty: 0.60115607
p_int: 0.978962245
p_ni: 0.0148253
p_wrong: 0.006212455
Data Source: BioPlex
Publication Statistics
PubMed Score  2.10

PubMed score by year
PubTator Score  2.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer