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Tbio
IL12RB2
Interleukin-12 receptor subunit beta-2

Protein Summary
Description
Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been fo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262345
  • ENSP00000262345
  • ENSG00000081985
  • ENST00000371000
  • ENSP00000360039
  • ENST00000544434
  • ENSP00000442443
  • ENST00000648487
  • ENSP00000497959
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.77
protein domain
0.73
cell type or tissue
0.69
disease
0.67
gene perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.82   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 323   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.82   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 323   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (21)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-12 family signaling
Reactome
Interleukin-12 signaling
Reactome
Interleukin-35 Signalling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-12 family signaling
Interleukin-12 signaling
Interleukin-35 Signalling
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (122)
1 – 10 of 122
HLA-A
Tbio
Novelty: 0.00378961
p_int: 0.895485516
p_ni: 0.104514484
Score: 0.198
Data Source: BioPlex,STRINGDB
IL12RB1
Tbio
Novelty: 0.00474176
Score: 0.985
Data Source: Reactome,STRINGDB
STAT4
Tbio
Family: TF
Novelty: 0.00296176
Score: 0.978
Data Source: Reactome,STRINGDB
IL12B
Tclin
Novelty: 0.01776322
Score: 0.972
Data Source: Reactome,STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00028252
Score: 0.957
Data Source: Reactome,STRINGDB
IL12A
Tclin
Novelty: 0.07686676
Score: 0.951
Data Source: Reactome,STRINGDB
IL4
Tbio
Novelty: 0.00010156
Score: 0.943
Data Source: STRINGDB
STAT1
Tchem
Family: TF
Novelty: 0.00041067
Score: 0.94
Data Source: Reactome,STRINGDB
IL6ST
Tclin
Novelty: 0.01731532
Score: 0.937
Data Source: Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00013496
Score: 0.937
Data Source: STRINGDB
Publication Statistics
PubMed Score  33.82

PubMed score by year
PubTator Score  56.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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