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Tbio
IL12RB2
Interleukin-12 receptor subunit beta-2

Protein Summary
Description
Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been fo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262345
  • ENSP00000262345
  • ENSG00000081985
  • ENST00000371000
  • ENSP00000360039
  • ENST00000544434
  • ENSP00000442443
  • ENST00000648487
  • ENSP00000497959
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.77
protein domain
0.73
cell type or tissue
0.69
disease
0.67
gene perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.5   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 323   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.5   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 323   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (122)
P10314
Tbio
Novelty:  0.00270731
p_int:  0.895485516
p_ni:  0.104514484
Score:  0.198
Data Source:  BioPlex,STRINGDB
IL12RB1
Tbio
Novelty:  0.00398741
Score:  0.985
Data Source:  Reactome,STRINGDB
STAT4
Tchem
Family:  TF
Novelty:  0.00251747
Score:  0.978
Data Source:  Reactome,STRINGDB
IL12B
Tclin
Novelty:  0.0157417
Score:  0.972
Data Source:  Reactome,STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.957
Data Source:  Reactome,STRINGDB
IL12A
Tclin
Novelty:  0.05943184
Score:  0.951
Data Source:  Reactome,STRINGDB
IL4
Tbio
Novelty:  0.00005852
Score:  0.943
Data Source:  STRINGDB
STAT1
Tchem
Family:  TF
Novelty:  0.0003383
Score:  0.94
Data Source:  Reactome,STRINGDB
IL6ST
Tclin
Novelty:  0.01026472
Score:  0.937
Data Source:  Reactome,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.937
Data Source:  STRINGDB
Nearest Tclin Targets (9)
Explore Nearest Tclin Targets
Pathways (21)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-12 family signaling
Reactome
Interleukin-12 signaling
Reactome
Interleukin-35 Signalling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-12 family signaling
Interleukin-12 signaling
Interleukin-35 Signalling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
4
1
2.6
99.6
5
3
1
1.7
99
4
4
2
1.1
98.9
primary biliary cirrhosis
4
2
2
1.6
97.8
2
1
0
2.3
95.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
2.6
99.6
1
1.7
99
2
1.1
98.9
primary biliary cirrhosis
2
1.6
97.8
0
2.3
95.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 12 receptor subunit beta 2
VGNC:6886
469348
Macaque
interleukin 12 receptor subunit beta 2
700677
Mouse
MGI:1270861
16162
Rat
RGD:620026
171334
Dog
interleukin 12 receptor subunit beta 2
VGNC:41935
489550
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 12 receptor subunit beta 2
Macaque
interleukin 12 receptor subunit beta 2
Mouse
Rat
Dog
interleukin 12 receptor subunit beta 2
Publication Statistics
PubMed Score 50.50
PubMed score by year
PubTator Score 56.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title