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Tbio
RAD9A
Cell cycle checkpoint control protein RAD9A

Protein Summary
Description
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307980
  • ENSP00000311360
  • ENSG00000172613

Symbol
  • RAD9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
hub protein
0.85
kinase
0.84
transcription factor binding site profile
0.73
biological process
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.67   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 1073   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.67   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 1073   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
3
3
97.1
mean reticulocyte volume
1
3
3
94.9
mean corpuscular volume
2
3
3
94
BMI-adjusted waist circumference
2
3
4
93.9
mean corpuscular hemoglobin concentration
2
2
2
89
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
97.1
mean reticulocyte volume
3
94.9
mean corpuscular volume
3
94
BMI-adjusted waist circumference
4
93.9
mean corpuscular hemoglobin concentration
2
89
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RAD9 checkpoint clamp component A
712345
Mouse
MGI:1328356
19367
Rat
RGD:2319938
100361529
Dog
RAD9 checkpoint clamp component A
VGNC:45322
483696
Horse
RAD9 checkpoint clamp component A [Source:HGNC Symbol;Acc:HGNC:9827]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RAD9 checkpoint clamp component A
Mouse
Rat
Dog
RAD9 checkpoint clamp component A
Horse
RAD9 checkpoint clamp component A [Source:HGNC Symbol;Acc:HGNC:9827]
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99638-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (32)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Cell Cycle
Cell Cycle Checkpoints
DNA Double-Strand Break Repair
DNA Repair
Gene Ontology Terms (17)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (169)
1 – 10 of 169
RAD1
Tchem
Novelty:  0.0060275
p_int:  0.999999933
p_ni:  2.3e-8
p_wrong:  4.4e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
HUS1
Tbio
Novelty:  0.00837493
p_int:  0.999999713
p_ni:  2.86e-7
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
HUS1B
Tdark
Novelty:  0.29267023
p_int:  0.999999672
p_ni:  6.9e-8
p_wrong:  2.59e-7
Score:  0.989
Data Source:  BioPlex,STRINGDB
TOPBP1
Tbio
Family:  Enzyme
Novelty:  0.00735579
Score:  0.997
Data Source:  STRINGDB
RAD17
Tbio
Novelty:  0.00640979
Score:  0.995
Data Source:  STRINGDB
ATR
Tchem
Family:  Kinase
Novelty:  0.00196978
Score:  0.993
Data Source:  STRINGDB
ATM
Tchem
Family:  Kinase
Novelty:  0.00019169
Score:  0.993
Data Source:  STRINGDB
CHEK1
Tchem
Family:  Kinase
Novelty:  0.00066843
Score:  0.992
Data Source:  STRINGDB
CLSPN
Tbio
Novelty:  0.01330727
Score:  0.988
Data Source:  STRINGDB
BRCA1
Tchem
Novelty:  0.00011146
Score:  0.987
Data Source:  STRINGDB
Publication Statistics
PubMed Score  169.67

PubMed score by year
PubTator Score  113.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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