Tbio CDX2 Homeobox protein CDX-2

Protein Summary

Description

Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536). This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• Q99626
• O00503
• Q5VTU7
• Q969L8
• Q9UD92

Gene Name

• CDX2

Ensembl ID

• ENST00000381020
• ENSP00000370408
• ENSG00000165556

Symbol

• CDX3
• CDX3
• CDX-3
• CDX2/AS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.86
biological process	0.85
protein domain	0.85
biological term	0.78
cell type or tissue	0.72

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Homeodomain Transcription Factor / Homeobox Protein Cdx-2

Protein / Nucleic Acid Binding / Dna Binding Protein / Homeobox Protein Cdx-2

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Homeodomain Transcription Factor / Homeobox Protein Cdx-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1579.88   (req: < 5)

Gene RIFs: 351   (req: <= 3)

Antibodies: 984   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1579.88   (req: >= 5)

Gene RIFs: 351   (req: > 3)

Antibodies: 984   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0