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Tbio
SLC38A3
Sodium-coupled neutral amino acid transporter 3

Protein Summary
Description
Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000614032
  • ENSP00000481301
  • ENSG00000188338

Symbol
  • G17
  • NAT1
  • SN1
  • SNAT3
  • G17
  • SN1
  • NAT1
  • SNAT3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
transcription factor perturbation
0.68
transcription factor
0.65
tissue
0.62
PubMedID
0.59


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1171.26   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1171.26   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
7
15
99.5
reticulocyte count
2
4
8
98.7
self reported educational attainment
5
5
4
7.2
98
intelligence
4
11
7
6.7
92.8
body mass index
2
2
2
91.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
15
99.5
reticulocyte count
8
98.7
self reported educational attainment
4
7.2
98
intelligence
7
6.7
92.8
body mass index
2
91.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 38 member 3
703671
Mouse
MGI:1923507
76257
Rat
RGD:628620
252919
Dog
solute carrier family 38 member 3
VGNC:46394
476617
Horse
solute carrier family 38 member 3
VGNC:23192
100062146
Species
Name
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 38 member 3
Mouse
Rat
Dog
solute carrier family 38 member 3
Horse
solute carrier family 38 member 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q99624-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Gene Ontology Terms (22)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (33)
1 – 10 of 33
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.998788922
p_ni:  0.000001025
p_wrong:  0.001210053
Score:  0.192
Data Source:  BioPlex,STRINGDB
SLC38A5
Tbio
Family:  Transporter
Novelty:  0.0202197
Score:  0.807
Data Source:  STRINGDB
SCN11A
Tclin
Family:  IC
Novelty:  0.00145294
Score:  0.757
Data Source:  STRINGDB
SLC1A7
Tchem
Family:  Transporter
Novelty:  0.00067678
Score:  0.689
Data Source:  STRINGDB
SLC32A1
Tchem
Family:  Transporter
Novelty:  0.00237273
Score:  0.657
Data Source:  STRINGDB
SLC1A5
Tchem
Family:  Transporter
Novelty:  0.00201741
Score:  0.644
Data Source:  STRINGDB
SLC1A2
Tchem
Family:  Transporter
Novelty:  0.00086733
Score:  0.627
Data Source:  STRINGDB
SLC22A12
Tclin
Family:  Transporter
Novelty:  0.00318081
Score:  0.616
Data Source:  STRINGDB
SLC1A1
Tchem
Family:  Transporter
Novelty:  0.00218479
Score:  0.59
Data Source:  STRINGDB
SLC1A3
Tchem
Family:  Transporter
Novelty:  0.00127305
Score:  0.588
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1171.26

PubMed score by year
PubTator Score  258.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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