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Tbio
PHB2
Prohibitin-2

Protein Summary
Description
Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000440277
  • ENSP00000412856
  • ENSG00000215021
  • ENST00000535923
  • ENSP00000441875

Symbol
  • BAP
  • REA
  • BAP
  • REA
  • p22
  • hBAP
  • Bap37
  • BCAP37
  • PNAS-141
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
kinase perturbation
1
co-expressed gene
0.91
gene perturbation
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.07   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 436   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.07   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 436   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
docosapentaenoic acid measurement
1
1
1
88.5
fatty acid measurement
1
1
1
88.5
linolenic acid measurement
1
1
1
88.5
arachidonic acid measurement
1
1
1
88.5
oleic acid measurement
1
1
1
88.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
docosapentaenoic acid measurement
1
88.5
fatty acid measurement
1
88.5
linolenic acid measurement
1
88.5
arachidonic acid measurement
1
88.5
oleic acid measurement
1
88.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
prohibitin 2
714693
Mouse
MGI:102520
12034
Rat
RGD:620203
114766
Dog
prohibitin 2
VGNC:44476
486716
Horse
prohibitin 2
VGNC:21369
100052934
Species
Name
OMA
EggNOG
Inparanoid
Macaque
prohibitin 2
Mouse
Rat
Dog
prohibitin 2
Horse
prohibitin 2
Pathways (4)
Mitochondrial calcium ion transport (R-HSA-8949215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial calcium ion transport
Reactome
Processing of SMDT1
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Mitochondrial calcium ion transport
Processing of SMDT1
Transport of small molecules
Protein-Protein Interactions (167)
1 – 10 of 167
RIC3
Tbio
Novelty: 0.0162412
p_int: 0.999636197
p_ni: 0.000363803
Score: 0.221
Data Source: BioPlex,STRINGDB
NMRAL1
Tbio
Novelty: 0.06152541
p_int: 0.997871234
p_ni: 0.001918725
p_wrong: 0.000210041
Score: 0.691
Data Source: BioPlex,STRINGDB
XIAP
Tchem
Family: Enzyme
Novelty: 0.00062268
p_int: 0.997392218
p_ni: 0.002607782
Score: 0.245
Data Source: BioPlex,STRINGDB
PHB
Tbio
Novelty: 0.00178383
Score: 0.999
Data Source: Reactome,STRINGDB
AFG3L2
Tbio
Family: Enzyme
Novelty: 0.01770465
Score: 0.988
Data Source: Reactome,STRINGDB
SPG7
Tbio
Family: Enzyme
Novelty: 0.00463357
Score: 0.979
Data Source: Reactome,STRINGDB
ESR1
Tclin
Family: NR
Novelty: 0.00005938
Score: 0.964
Data Source: STRINGDB
UQCRC1
Tbio
Family: Enzyme
Novelty: 0.01746759
Score: 0.952
Data Source: STRINGDB
PMPCB
Tbio
Family: Enzyme
Novelty: 0.0244013
Score: 0.94
Data Source: Reactome,STRINGDB
PMPCA
Tbio
Family: Enzyme
Novelty: 0.01842996
Score: 0.935
Data Source: STRINGDB
Publication Statistics
PubMed Score  224.07

PubMed score by year
PubTator Score  591.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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