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Tbio
SPSB2
SPRY domain-containing SOCS box protein 2

Protein Summary
Description
Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). This gene encodes a member of a subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal suppressor of cytokine signaling (SOCS) box. This protein plays a role in cell signaling. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000519357
  • ENSP00000431037
  • ENSG00000111671
  • ENST00000523102
  • ENSP00000430872
  • ENST00000524270
  • ENSP00000428338

Symbol
  • GRCC9
  • SSB2
  • SSB2
  • GRCC9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.79
transcription factor binding site profile
0.76
cell line
0.6
transcription factor
0.6
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.2   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.2   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
65.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
65.5
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (309)
1 – 10 of 309
EPHB2
Tchem
Family: Kinase
Novelty: 0.00211785
p_int: 0.999999981
p_ni: 1.7e-8
p_wrong: 2e-9
Score: 0.557
Data Source: BioPlex,STRINGDB
CUL5
Tbio
Novelty: 0.00792494
p_int: 0.999999954
p_ni: 4.6e-8
Score: 0.957
Data Source: BioPlex,STRINGDB
TTC1
Tbio
Novelty: 0.01389711
p_int: 0.999999927
p_ni: 7.3e-8
Score: 0.211
Data Source: BioPlex,STRINGDB
ARHGEF10
Tbio
Novelty: 0.04928387
p_int: 0.998873259
p_ni: 0.001108711
p_wrong: 0.00001803
Score: 0.218
Data Source: BioPlex,STRINGDB
RNF7
Tbio
Novelty: 0.02532658
p_int: 0.976122917
p_ni: 2.92e-7
p_wrong: 0.023876792
Score: 0.941
Data Source: BioPlex,STRINGDB
CISH
Tbio
Novelty: 0.00145893
Score: 0.969
Data Source: STRINGDB
ELOC
Tbio
Novelty: 0.00964847
Score: 0.961
Data Source: STRINGDB
STUB1
Tbio
Family: Enzyme
Novelty: 0.00055102
Score: 0.938
Data Source: STRINGDB
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
Score: 0.936
Data Source: STRINGDB
ELOB
Tbio
Novelty: 0.01315739
Score: 0.933
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.20

PubMed score by year
PubTator Score  11.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer