Tbio CCL13 C-C motif chemokine 13

Protein Summary

Description

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014]

Uniprot Accession IDs

• Q99616
• O95689
• Q6ICQ6

Gene Name

• CCL13

Ensembl ID

• ENST00000225844
• ENSP00000225844
• ENSG00000181374

Symbol

• MCP4
• NCC1
• SCYA13
• NCC1
• CKb10
• MCP-4
• NCC-1
• SCYL1
• SCYA13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.83
phenotype	0.81
virus perturbation	0.76
PubMedID	0.67
gene perturbation	0.6

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Chemokine / C-c Motif Chemokine 13

DTO Classes

Protein / Signaling / Chemokine / C-c Motif Chemokine 13

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.9   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 376   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.9   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 376   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0