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Tbio
CCL13
C-C motif chemokine 13

Protein Summary
Description
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225844
  • ENSP00000225844
  • ENSG00000181374

Symbol
  • MCP4
  • NCC1
  • SCYA13
  • NCC1
  • CKb10
  • MCP-4
  • NCC-1
  • SCYL1
  • SCYA13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
phenotype
0.81
virus perturbation
0.76
PubMedID
0.67
gene perturbation
0.6


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.95   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 376   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.95   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 376   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
C-C motif chemokine ligand 13
714907
Dog
chemokine (C-C motif) ligand 13
445451
Horse
chemokine (C-C motif) ligand 13
100033951
Species
Name
OMA
EggNOG
Inparanoid
Macaque
C-C motif chemokine ligand 13
Dog
chemokine (C-C motif) ligand 13
Horse
chemokine (C-C motif) ligand 13
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99616-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (26)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (254)
1 – 10 of 254
CCR5
Tclin
Family: GPCR
Novelty: 0.00022549
Score: 0.979
Data Source: STRINGDB
CCR3
Tchem
Family: GPCR
Novelty: 0.00197059
Score: 0.977
Data Source: Reactome,STRINGDB
CXCL10
Tchem
Novelty: 0.00040194
Score: 0.974
Data Source: STRINGDB
CCR2
Tchem
Family: GPCR
Novelty: 0.0006525
Score: 0.972
Data Source: Reactome,STRINGDB
CCR1
Tchem
Family: GPCR
Novelty: 0.00218065
Score: 0.972
Data Source: STRINGDB
CXCL9
Tbio
Novelty: 0.00073213
Score: 0.971
Data Source: STRINGDB
CXCL11
Tbio
Novelty: 0.00077765
Score: 0.971
Data Source: STRINGDB
CCL21
Tbio
Novelty: 0.00130736
Score: 0.966
Data Source: STRINGDB
CCL19
Tbio
Novelty: 0.00169711
Score: 0.963
Data Source: STRINGDB
CXCL12
Tbio
Novelty: 0.00026817
Score: 0.962
Data Source: STRINGDB
Publication Statistics
PubMed Score  158.95

PubMed score by year
PubTator Score  93.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer