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Tbio
DNAJC7
DnaJ homolog subfamily C member 7

Protein Summary
Description
Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity). This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316603
  • ENSP00000313311
  • ENSG00000168259
  • ENST00000426588
  • ENSP00000394327
  • ENST00000457167
  • ENSP00000406463

Symbol
  • TPR2
  • TTC2
  • DJ11
  • DJC7
  • TPR2
  • TTC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
interacting protein
0.96
disease perturbation
0.9
transcription factor binding site profile
0.88
protein domain
0.85


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.09   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.09   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C7
VGNC:9264
454674
Macaque
DnaJ heat shock protein family (Hsp40) member C7
708729
Mouse
MGI:1928373
56354
Rat
RGD:1303226
303536
Dog
DnaJ heat shock protein family (Hsp40) member C7
480519
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C7
Macaque
DnaJ heat shock protein family (Hsp40) member C7
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member C7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q99615-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (24)
Cellular response to heat stress (R-HSA-3371556)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Regulation of HSF1-mediated heat shock response
Name
Explore in Pharos
Explore in Source
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Regulation of HSF1-mediated heat shock response
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (122)
1 – 10 of 122
EML5
Tdark
Novelty: 0.29826509
p_int: 0.999998134
p_ni: 0.000001866
Score: 0.154
Data Source: BioPlex,STRINGDB
VPS13B
Tbio
Novelty: 0.02154769
p_int: 0.999994013
p_ni: 0.000005987
Data Source: BioPlex
BBS10
Tbio
Novelty: 0.03343798
p_int: 0.999988044
p_ni: 0.000011906
p_wrong: 5e-8
Score: 0.237
Data Source: BioPlex,STRINGDB
KIAA0100
Tbio
Novelty: 0.10510857
p_int: 0.999984856
p_ni: 0.000015144
Score: 0.201
Data Source: BioPlex,STRINGDB
NPHP1
Tbio
Novelty: 0.01113034
p_int: 0.999979188
p_ni: 0.000020218
p_wrong: 5.93e-7
Data Source: BioPlex
FANCB
Tbio
Novelty: 0.00268111
p_int: 0.999949015
p_ni: 0.000050984
p_wrong: 1e-9
Score: 0.183
Data Source: BioPlex,STRINGDB
URGCP
Tbio
Novelty: 0.05171079
p_int: 0.999582947
p_ni: 0.000017371
p_wrong: 0.000399683
Score: 0.199
Data Source: BioPlex,STRINGDB
WDR41
Tbio
Novelty: 0.20400077
p_int: 0.99948209
p_ni: 0.000475309
p_wrong: 0.000042601
Data Source: BioPlex
GREB1
Tbio
Novelty: 0.01644388
p_int: 0.997539863
p_ni: 0.002446575
p_wrong: 0.000013561
Score: 0.188
Data Source: BioPlex,STRINGDB
C5orf34
Tdark
Novelty: 1.01063928
p_int: 0.994410052
p_ni: 0.005589948
Data Source: BioPlex
Publication Statistics
PubMed Score  41.09

PubMed score by year
PubTator Score  19.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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