EIF3C
Eukaryotic translation initiation factor 3 subunit C
Protein Summary
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repressi ...more
- ENST00000331666
- ENSP00000332604
- ENSG00000184110
- ENST00000395587
- ENSP00000378953
- ENST00000564243
- ENSP00000456416
- ENST00000566501
- ENSP00000457963
- ENST00000566866
- ENSP00000457418
- EIF3S8
- EIF3CL
- EIF3S8
- eIF3-p110
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
drug perturbation | 0.99 | ||
small molecule perturbation | 0.99 | ||
disease perturbation | 0.96 | ||
transcription factor perturbation | 0.96 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 38.98 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 215 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 38.98 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 215 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0