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Tbio
EIF3C
Eukaryotic translation initiation factor 3 subunit C

Protein Summary
Description
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repressi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331666
  • ENSP00000332604
  • ENSG00000184110
  • ENST00000395587
  • ENSP00000378953
  • ENST00000564243
  • ENSP00000456416
  • ENST00000566501
  • ENSP00000457963
  • ENST00000566866
  • ENSP00000457418

Symbol
  • EIF3S8
  • EIF3CL
  • EIF3S8
  • eIF3-p110
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
drug perturbation
0.99
small molecule perturbation
0.99
disease perturbation
0.96
transcription factor perturbation
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.14   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.14   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (268)
EIF3E
Tbio
Novelty:  0.02154456
p_int:  0.999978771
p_ni:  0.000021229
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3I
Tbio
Novelty:  0.04398155
p_int:  0.999975886
p_ni:  0.000024114
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3H
Tbio
Novelty:  0.02564681
p_int:  0.999971676
p_ni:  0.000028324
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3L
Tbio
Novelty:  0.11054104
p_int:  0.999967685
p_ni:  0.000032315
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3M
Tbio
Novelty:  0.0174915
p_int:  0.99996566
p_ni:  0.00003434
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3D
Tbio
Novelty:  0.0360717
p_int:  0.99990446
p_ni:  0.00009554
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3F
Tbio
Novelty:  0.0319772
p_int:  0.999836791
p_ni:  0.000163209
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3G
Tbio
Novelty:  0.04737601
p_int:  0.997913734
p_ni:  0.002086266
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF4A1
Tchem
Novelty:  0.00269994
p_int:  0.963334917
p_ni:  0.036665083
Score:  0.988
Data Source:  BioPlex,STRINGDB
PSMD12
Tbio
Family:  Enzyme
Novelty:  0.03178037
p_int:  0.915398131
p_ni:  0.084601869
Score:  0.671
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Cap-dependent Translation Initiation
Reactome
Eukaryotic Translation Initiation
Reactome
Formation of a pool of free 40S subunits
Reactome
Formation of the ternary complex, and subsequently, the 43S complex
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Cap-dependent Translation Initiation
Eukaryotic Translation Initiation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
5
11
6
6.6
94
red blood cell density measurement
1
1
1
81.6
cognitive function measurement
1
1
1
81.3
self reported educational attainment
2
2
1
7.6
72.4
body fat percentage
1
1
2
68
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
6
6.6
94
red blood cell density measurement
1
81.6
cognitive function measurement
1
81.3
self reported educational attainment
1
7.6
72.4
body fat percentage
2
68
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
eukaryotic translation initiation factor 3 subunit C
705696
Mouse
MGI:1926966
56347
Rat
RGD:1308871
293484
Cow
eukaryotic translation initiation factor 3, subunit C-like
534882
Anole lizard
eukaryotic translation initiation factor 3 subunit C
100555291
Species
Name
OMA
EggNOG
Inparanoid
Macaque
eukaryotic translation initiation factor 3 subunit C
Mouse
Rat
Cow
eukaryotic translation initiation factor 3, subunit C-like
Anole lizard
eukaryotic translation initiation factor 3 subunit C
Publication Statistics
PubMed Score 34.14
PubMed score by year
PubTator Score 10.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title