Tbio EIF3C Eukaryotic translation initiation factor 3 subunit C

Protein Summary

Description

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Uniprot Accession IDs

• Q99613
• A8K7Z0
• B2RXG3
• B4E1D5
• H3BRV0
• O00215
• Q9BW98
• eIF3c

Gene Name

• EIF3C

Ensembl ID

• ENST00000331666
• ENSP00000332604
• ENSG00000184110
• ENST00000395587
• ENSP00000378953
• ENST00000564243
• ENSP00000456416
• ENST00000566501
• ENSP00000457963
• ENST00000566866
• ENSP00000457418

Symbol

• EIF3S8
• EIF3CL
• EIF3S8
• eIF3-p110

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
drug perturbation	0.99
small molecule perturbation	0.99
disease perturbation	0.96
transcription factor perturbation	0.96

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 3 Subunit C

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 3 Subunit C

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.98   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 215   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.98   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0