Tbio EIF3C Eukaryotic translation initiation factor 3 subunit C

Protein Summary

Description

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Uniprot Accession IDs

• Q99613
• A8K7Z0
• B2RXG3
• B4E1D5
• H3BRV0
• O00215
• Q9BW98
• eIF3c

Gene Name

• EIF3C

Ensembl ID

• ENST00000331666
• ENSP00000332604
• ENSG00000184110
• ENST00000395587
• ENSP00000378953
• ENST00000564243
• ENSP00000456416
• ENST00000566501
• ENSP00000457963
• ENST00000566866
• ENSP00000457418

Symbol

• EIF3S8
• EIF3CL
• EIF3S8
• eIF3-p110

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
drug perturbation	0.99
small molecule perturbation	0.99
disease perturbation	0.96
transcription factor perturbation	0.96

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 3 Subunit C

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 3 Subunit C

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.14   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 215   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.14   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (268)

Explore Interacting Targets

1 – 10 of 268

• See Interactions on String-DB

EIF3E

Tbio

Novelty:  0.02154456

p_int:  0.999978771

p_ni:  0.000021229

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3I

Tbio

Novelty:  0.04398155

p_int:  0.999975886

p_ni:  0.000024114

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3H

Tbio

Novelty:  0.02564681

p_int:  0.999971676

p_ni:  0.000028324

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3L

Tbio

Novelty:  0.11054104

p_int:  0.999967685

p_ni:  0.000032315

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3M

Tbio

Novelty:  0.0174915

p_int:  0.99996566

p_ni:  0.00003434

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3D

Tbio

Novelty:  0.0360717

p_int:  0.99990446

p_ni:  0.00009554

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3F

Tbio

Novelty:  0.0319772

p_int:  0.999836791

p_ni:  0.000163209

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3G

Tbio

Novelty:  0.04737601

p_int:  0.997913734

p_ni:  0.002086266

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF4A1

Tchem

Novelty:  0.00269994

p_int:  0.963334917

p_ni:  0.036665083

Score:  0.988

Data Source:  BioPlex,STRINGDB

PSMD12

Tbio

Family:  Enzyme

Novelty:  0.03178037

p_int:  0.915398131

p_ni:  0.084601869

Score:  0.671

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (13)

Reactome (11)

KEGG (1)

WikiPathways (1)

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	61 targets	R-HSA-72662
Reactome	Cap-dependent Translation Initiation	121 targets	R-HSA-72737
Reactome	Eukaryotic Translation Initiation	121 targets	R-HSA-72613
Reactome	Formation of a pool of free 40S subunits	103 targets	R-HSA-72689
Reactome	Formation of the ternary complex, and subsequently, the 43S complex	53 targets	R-HSA-72695

Name	Explore in Pharos	Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	61 targets	R-HSA-72662
Cap-dependent Translation Initiation	121 targets	R-HSA-72737
Eukaryotic Translation Initiation	121 targets	R-HSA-72613
Formation of a pool of free 40S subunits	103 targets	R-HSA-72689
Formation of the ternary complex, and subsequently, the 43S complex	53 targets	R-HSA-72695

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (3)

Components (4)

Processes (4)

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1 – 3 of 3

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
translation initiation factor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
translation initiation factor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-UniRule

Disease Associations ()

No disease associations found

GWAS Traits (18)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 18

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
intelligence	EFO_0004337	5	11	6	6.6	94
red blood cell density measurement	EFO_0007978	1	1	1		81.6
cognitive function measurement	EFO_0008354	1	1	1		81.3
self reported educational attainment	EFO_0004784	2	2	1	7.6	72.4
body fat percentage	EFO_0007800	1	1	2		68

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 18

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
intelligence	EFO_0004337	6	6.6	94
red blood cell density measurement	EFO_0007978	1		81.6
cognitive function measurement	EFO_0008354	1		81.3
self reported educational attainment	EFO_0004784	1	7.6	72.4
body fat percentage	EFO_0007800	2		68

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Initiation factor
Phosphoprotein
Protein biosynthesis
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
alcohol consumption measurement
allergic rhinitis
BMI-adjusted hip circumference
body fat percentage
body mass index
C-reactive protein measurement
caudate nucleus volume
chronic lymphocytic leukemia
cognitive function measurement
electrocardiography

MGI Phenotype Find Similar Targets

No Header	No Header
craniofacial phenotype
growth/size/body region phenotype
hearing/vestibular/ear phenotype
integument phenotype
limbs/digits/tail phenotype
mortality/aging
pigmentation phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	eukaryotic translation initiation factor 3 subunit C		705696
Mouse	eukaryotic translation initiation factor 3, subunit C	MGI:1926966	56347
Rat	eukaryotic translation initiation factor 3, subunit C	RGD:1308871	293484
Cow	eukaryotic translation initiation factor 3, subunit C-like		534882
Anole lizard	eukaryotic translation initiation factor 3 subunit C		100555291

Species	Name	OMA	EggNOG	Inparanoid
Macaque	eukaryotic translation initiation factor 3 subunit C
Mouse	eukaryotic translation initiation factor 3, subunit C
Rat	eukaryotic translation initiation factor 3, subunit C
Cow	eukaryotic translation initiation factor 3, subunit C-like
Anole lizard	eukaryotic translation initiation factor 3 subunit C

Publication Statistics

PubMed Score 34.14

PubMed score by year

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PubTator Score 10.07

PubTator score by year

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Related Publications

Text Mined References (41)

GeneRif Annotations (8)

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10

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PMID	Year	Title