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Tbio
ELF4
ETS-related transcription factor Elf-4

Protein Summary
Description
Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308167
  • ENSP00000311280
  • ENSG00000102034
  • ENST00000335997
  • ENSP00000338608

Symbol
  • ELFR
  • MEF
  • MEF
  • ELFR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
transcription factor perturbation
0.88
molecular function
0.79
virus perturbation
0.79
PubMedID
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.35   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 321   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.35   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (30)
1 – 10 of 30
KLF4
Tbio
Family:  TF
Novelty:  0.00076828
Score:  0.675
Data Source:  STRINGDB
KLF2
Tbio
Family:  TF
Novelty:  0.00290947
Score:  0.644
Data Source:  STRINGDB
PRR7
Tbio
Novelty:  0.08132975
Score:  0.562
Data Source:  STRINGDB
LRRC30
Tdark
Novelty:  2.30668103
Score:  0.536
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.532
Data Source:  STRINGDB
SELL
Tchem
Novelty:  0.00030025
Score:  0.531
Data Source:  STRINGDB
PRR5
Tbio
Novelty:  0.03269368
Score:  0.519
Data Source:  STRINGDB
MDM2
Tchem
Family:  Enzyme
Novelty:  0.00028385
Score:  0.513
Data Source:  STRINGDB
PRR9
Tdark
Novelty:  0.09345601
Score:  0.498
Data Source:  STRINGDB
MAPK8
Tchem
Family:  Kinase
Novelty:  0.00055723
Score:  0.496
Data Source:  STRINGDB
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
1
1
47.7
sex hormone-binding globulin measurement
4
1
4
43.8
neutrophil count
1
1
1
31.4
hematocrit
1
1
1
30.2
body height
1
1
1
14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
47.7
sex hormone-binding globulin measurement
4
43.8
neutrophil count
1
31.4
hematocrit
1
30.2
body height
1
14
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
E74 like ETS transcription factor 4
702886
Mouse
MGI:1928377
56501
Rat
RGD:1560743
302811
Dog
E74 like ETS transcription factor 4
VGNC:40301
492129
Horse
E74 like ETS transcription factor 4
VGNC:17521
100054591
Species
Name
OMA
EggNOG
Inparanoid
Macaque
E74 like ETS transcription factor 4
Mouse
Rat
Dog
E74 like ETS transcription factor 4
Horse
E74 like ETS transcription factor 4
Publication Statistics
PubMed Score 43.35
PubMed score by year
PubTator Score 270.78
PubTator score by year