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Tbio
TEAD3
Transcriptional enhancer factor TEF-5

Protein Summary
Description
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000639578
  • ENSP00000492431
  • ENSG00000007866

Symbol
  • TEAD5
  • TEF5
  • TEF5
  • TEAD5
  • TEF-5
  • DTEF-1
  • ETFR-1
  • TEAD-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.74
biological process
0.64
transcription factor binding site profile
0.63
histone modification site profile
0.62
transcription factor
0.62


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.91   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 237   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.91   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
TEA domain transcription factor 3
100429858
Mouse
MGI:109241
21678
Rat
RGD:1311583
294299
Dog
TEA domain transcription factor 3
VGNC:47230
100855973
Horse
TEA domain transcription factor 3
VGNC:23980
100063075
Species
Name
OMA
EggNOG
Inparanoid
Macaque
TEA domain transcription factor 3
Mouse
Rat
Dog
TEA domain transcription factor 3
Horse
TEA domain transcription factor 3
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX3 regulates YAP1-mediated transcription
Reactome
Transcriptional regulation by RUNX3
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX3 regulates YAP1-mediated transcription
Transcriptional regulation by RUNX3
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
WormBase
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (60)
1 – 10 of 60
VGLL4
Tbio
Novelty: 0.03384856
p_int: 0.999999996
p_ni: 1e-9
p_wrong: 3e-9
Score: 0.774
Data Source: BioPlex,STRINGDB
WWTR1
Tbio
Novelty: 0.00431186
p_int: 0.999949264
p_ni: 2.4e-8
p_wrong: 0.000050712
Score: 0.977
Data Source: BioPlex,Reactome,STRINGDB
YAP1
Tbio
Novelty: 0.00124225
Score: 0.996
Data Source: Reactome,STRINGDB
CTGF
Tbio
Novelty: 0.0004346
Score: 0.946
Data Source: STRINGDB
TEAD1
Tbio
Family: TF
Novelty: 0.01198524
Score: 0.916
Data Source: STRINGDB
TEAD2
Tbio
Family: TF
Novelty: 0.02487024
Score: 0.914
Data Source: STRINGDB
TEAD4
Tbio
Family: TF
Novelty: 0.0114979
Score: 0.913
Data Source: STRINGDB
RUNX3
Tbio
Family: TF
Novelty: 0.00144472
Score: 0.902
Data Source: STRINGDB
TCF7L2
Tbio
Family: TF
Novelty: 0.00178694
Score: 0.846
Data Source: STRINGDB
TCF7L1
Tbio
Family: TF
Novelty: 0.03807371
Score: 0.815
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.91

PubMed score by year
PubTator Score  6.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer