Tbio TBX5 T-box transcription factor TBX5

Protein Summary

Description

DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation (PubMed:25725155, PubMed:25963046, PubMed:29174768, PubMed:26917986, PubMed:27035640, PubMed:8988164). Binds to the core DNA motif of NPPA promoter (PubMed:26926761). This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q99593
• A6ND77
• O15301
• Q96TB0
• Q9Y4I2
• T-box protein 5

Gene Name

• TBX5

Ensembl ID

• ENST00000310346
• ENSP00000309913
• ENSG00000089225
• ENST00000349716
• ENSP00000337723
• ENST00000405440
• ENSP00000384152
• ENST00000526441
• ENSP00000433292

Symbol

• HOS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
co-expressed gene	0.97
trait	0.75
cell line	0.7
disease	0.69

Protein Classes

PANTHER Classes

Protein / Transcription Factor / T-box Transcription Factor Tbx5

Protein / Nucleic Acid Binding / T-box Transcription Factor Tbx5

Protein / ... / Rel Homology Transcription Factor / T-box Transcription Factor Tbx5

DTO Classes

Protein / Transcription Factor / Immunoglobulin Fold Transcription Factor / Rel Homology Transcription Factor / T-box Transcription Factor Tbx5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 435.56   (req: < 5)

Gene RIFs: 108   (req: <= 3)

Antibodies: 244   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 435.56   (req: >= 5)

Gene RIFs: 108   (req: > 3)

Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0