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Tbio
ZBTB18
Zinc finger and BTB domain-containing protein 18

Protein Summary
Description
Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus. This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of chromatin to target genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358704
  • ENSP00000351539
  • ENSG00000179456
  • ENST00000622512
  • ENSP00000481278

Symbol
  • RP58
  • TAZ1
  • ZNF238
  • RP58
  • MRD22
  • TAZ-1
  • ZNF238
  • C2H2-171
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor
0.82
microRNA
0.74
transcription factor perturbation
0.74
small molecule perturbation
0.67


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.72   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.72   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger and BTB domain containing 18
VGNC:10877
469733
Macaque
zinc finger and BTB domain containing 18
714294
Mouse
MGI:1353609
30928
Rat
RGD:621548
64619
Dog
zinc finger and BTB domain containing 18
VGNC:53842
490376
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger and BTB domain containing 18
Macaque
zinc finger and BTB domain containing 18
Mouse
Rat
Dog
zinc finger and BTB domain containing 18
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q99592-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (13)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (48)
1 – 10 of 48
ZBTB42
Tbio
Family:  TF
Novelty:  0.54038505
p_int:  0.999999996
p_wrong:  4e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
ATXN1L
Tbio
Novelty:  0.1105313
p_int:  0.999999923
p_ni:  5.5e-8
p_wrong:  2.2e-8
Score:  0.269
Data Source:  BioPlex,STRINGDB
CIC
Tbio
Family:  TF
Novelty:  0.01006338
p_int:  0.999999811
p_ni:  1.5e-8
p_wrong:  1.74e-7
Score:  0.288
Data Source:  BioPlex,STRINGDB
ZNF131
Tbio
Family:  TF
Novelty:  0.18894578
p_int:  0.999997966
p_ni:  0.000001979
p_wrong:  5.5e-8
Score:  0.228
Data Source:  BioPlex,STRINGDB
CYP4F12
Tbio
Novelty:  0.06142848
p_int:  0.999986283
p_ni:  0.000013469
p_wrong:  2.48e-7
Score:  0.197
Data Source:  BioPlex,STRINGDB
ZBTB3
Tdark
Family:  TF
Novelty:  0.34423886
p_int:  0.999969968
p_ni:  1.4e-7
p_wrong:  0.000029892
Score:  0.54
Data Source:  BioPlex,STRINGDB
CTBP1
Tbio
Novelty:  0.00243818
p_int:  0.996027499
p_ni:  0.003972501
Score:  0.177
Data Source:  BioPlex,STRINGDB
RCBTB2
Tbio
Novelty:  0.04244536
p_int:  0.974990453
p_ni:  0.025006045
p_wrong:  0.000003503
Score:  0.2
Data Source:  BioPlex,STRINGDB
TSN
Tbio
Novelty:  0.00510474
Score:  0.871
Data Source:  STRINGDB
CEP170
Tbio
Novelty:  0.05342931
Score:  0.736
Data Source:  STRINGDB
Publication Statistics
PubMed Score  30.72

PubMed score by year
PubTator Score  31.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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