Tbio ZBTB18 Zinc finger and BTB domain-containing protein 18

Protein Summary

Description

Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus. This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of chromatin to target genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Uniprot Accession IDs

• Q99592
• A8K5U3
• Q13397
• Q5VU40
• Q8N463
• Q9UD99

Gene Name

• ZBTB18

Ensembl ID

• ENST00000358704
• ENSP00000351539
• ENSG00000179456
• ENST00000622512
• ENSP00000481278

Symbol

• RP58
• TAZ1
• ZNF238
• RP58
• MRD22
• TAZ-1
• ZNF238
• C2H2-171

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
transcription factor	0.82
microRNA	0.74
transcription factor perturbation	0.74
small molecule perturbation	0.67

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Zinc Finger And Btb Domain-containing Protein 18

Protein / ... / Krab Box Transcription Factor / Zinc Finger And Btb Domain-containing Protein 18

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / C2h2 Zinc Finger Transcription Factor / Krab Box Transcription Factor / Zinc Finger And Btb Domain-containing Protein 18

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.22   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 101   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.22   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0