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Tbio
POP1
Ribonucleases P/MRP protein subunit POP1

Protein Summary
Description
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP. This gene encodes the protein subunit of two different small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is a ribonuclease that localizes to the nucleus and functions in pre-RNA processing. This protein is also an autoantigen in patients suffering from connective tissue diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349693
  • ENSP00000339529
  • ENSG00000104356
  • ENST00000401707
  • ENSP00000385787

Symbol
  • KIAA0061
  • ANXD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
histone modification site profile
0.89
interacting protein
0.87
hub protein
0.75
cellular component
0.7


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.32   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.32   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
POP1 homolog, ribonuclease P/MRP subunit
VGNC:8182
464303
Mouse
MGI:1914974
67724
Rat
RGD:1308609
315045
Dog
POP1 homolog, ribonuclease P/MRP subunit
VGNC:44815
481978
Horse
POP1 homolog, ribonuclease P/MRP subunit
VGNC:21697
100055680
Species
Name
OMA
EggNOG
Inparanoid
Chimp
POP1 homolog, ribonuclease P/MRP subunit
Mouse
Rat
Dog
POP1 homolog, ribonuclease P/MRP subunit
Horse
POP1 homolog, ribonuclease P/MRP subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q99575-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA processing
Reactome
tRNA processing in the nucleus
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA processing
tRNA processing in the nucleus
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (94)
1 – 10 of 94
POP5
Tbio
Family: Enzyme
Novelty: 0.02459167
p_int: 0.999829449
p_ni: 0.000170551
Score: 0.995
Data Source: BioPlex,STRINGDB
RPP21
Tbio
Family: Enzyme
Novelty: 0.05805689
p_int: 0.999798394
p_ni: 0.000201606
Score: 0.985
Data Source: BioPlex,STRINGDB
RPP25L
Tdark
Family: Enzyme
Novelty: 1.39761189
p_int: 0.999729081
p_ni: 0.000270919
Score: 0.821
Data Source: BioPlex,STRINGDB
RPP30
Tbio
Family: Enzyme
Novelty: 0.01375777
p_int: 0.999545488
p_ni: 0.000454512
Score: 0.995
Data Source: BioPlex,STRINGDB
POP4
Tbio
Family: Enzyme
Novelty: 0.01072287
p_int: 0.999405618
p_ni: 0.000594382
Score: 0.996
Data Source: BioPlex,STRINGDB
RPP25
Tbio
Family: Enzyme
Novelty: 0.07178063
p_int: 0.998933463
p_ni: 0.001066535
p_wrong: 1e-9
Score: 0.968
Data Source: BioPlex,STRINGDB
NEPRO
Tbio
Novelty: 0.12980261
p_int: 0.994294283
p_ni: 0.005705717
Score: 0.161
Data Source: BioPlex,STRINGDB
C18orf21
Tdark
Novelty: 0.65363998
p_int: 0.992963807
p_ni: 0.007036193
Score: 0.768
Data Source: BioPlex,STRINGDB
RBM4
Tbio
Novelty: 0.02034191
p_int: 0.958236547
p_ni: 0.041763453
Score: 0.154
Data Source: BioPlex,STRINGDB
NIFK
Tbio
Novelty: 0.01221562
p_int: 0.915431245
p_ni: 0.084568755
Score: 0.178
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  0.32

PubMed score by year
PubTator Score  29.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer