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Tbio
SERPINI1
Neuroserpin

Protein Summary
Description
Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:9442076, PubMed:26329378, PubMed:19265707, PubMed:19285087, PubMed:11880376). May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable). This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295777
  • ENSP00000295777
  • ENSG00000163536
  • ENST00000446050
  • ENSP00000397373

Symbol
  • PI12
  • PI12
  • neuroserpin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.93
transcription factor perturbation
0.88
small molecule perturbation
0.8
transcription factor
0.77
transcription factor binding site profile
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.15   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 412   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.15   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 412   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
PLG
Tclin
Family:  Enzyme
Novelty:  0.00004806
Score:  0.821
Data Source:  STRINGDB
PLAT
Tclin
Family:  Enzyme
Novelty:  0.00017503
Score:  0.805
Data Source:  STRINGDB
PDCD10
Tbio
Novelty:  0.00683934
Score:  0.79
Data Source:  STRINGDB
MAPT
Tclin
Novelty:  0.00013232
Score:  0.74
Data Source:  STRINGDB
PI15
Tbio
Family:  Enzyme
Novelty:  0.02244161
Score:  0.669
Data Source:  STRINGDB
RPE65
Tbio
Family:  Enzyme
Novelty:  0.00147985
Score:  0.63
Data Source:  STRINGDB
PTGER4
Tclin
Family:  GPCR
Novelty:  0.0008127
Score:  0.629
Data Source:  STRINGDB
PHB
Tbio
Novelty:  0.00178383
Score:  0.626
Data Source:  STRINGDB
P0C7T4
Tbio
Novelty:  0.05969952
Score:  0.604
Data Source:  STRINGDB
A8MTL9
Tdark
Novelty:  0.05969952
Score:  0.604
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
95.1
platelet count
1
1
1
68.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
95.1
platelet count
1
68.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serpin family I member 1
VGNC:10044
460834
Macaque
serpin family I member 1
699483
Mouse
MGI:1194506
20713
Rat
RGD:619896
116459
Dog
serpin family I member 1
VGNC:46042
478684
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serpin family I member 1
Macaque
serpin family I member 1
Mouse
Rat
Dog
serpin family I member 1
Publication Statistics
PubMed Score 209.15
PubMed score by year
PubTator Score 94.10
PubTator score by year
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Related Publications
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PMID
Year
Title