Protein Summary
Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:9442076, PubMed:26329378, PubMed:19265707, PubMed:19285087, PubMed:11880376). May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable). This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively s ...more
- ENST00000295777
- ENSP00000295777
- ENSG00000163536
- ENST00000446050
- ENSP00000397373
- PI12
- PI12
- neuroserpin
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.93 | ||
transcription factor perturbation | 0.88 | ||
small molecule perturbation | 0.8 | ||
transcription factor | 0.77 | ||
transcription factor binding site profile | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 209.15 (req: < 5)
Gene RIFs: 35 (req: <= 3)
Antibodies: 412 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 209.15 (req: >= 5)
Gene RIFs: 35 (req: > 3)
Antibodies: 412 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (45)
Nearest Tclin Targets
Pathways (1)
PathwayCommons (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: pid | Validated targets of C-MYC transcriptional activation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Validated targets of C-MYC transcriptional activation | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (1)
Components (6)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 3 | 3 | 95.1 | |||||
platelet count | 1 | 1 | 1 | 68.8 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 95.1 | |||||
platelet count | 1 | 68.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | serpin family I member 1 | VGNC:10044 | 460834 | |||||
Macaque | serpin family I member 1 | 699483 | ||||||
Mouse | MGI:1194506 | 20713 | ||||||
Rat | RGD:619896 | 116459 | ||||||
Dog | serpin family I member 1 | VGNC:46042 | 478684 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | serpin family I member 1 | |||||
Macaque | serpin family I member 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | serpin family I member 1 | |||||
Publication Statistics
PubMed Score 209.15
PubMed score by year
PubTator Score 94.10
PubTator score by year
Related Publications
Text Mined References (54)
GeneRif Annotations (35)
Items per page:
0 of 0
PMID | Year | Title |
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