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Tchem
P2RX7
P2X purinoceptor 7

Protein Summary
Description
Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206). The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, J ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328963
  • ENSP00000330696
  • ENSG00000089041
  • ENST00000535250
  • ENSP00000442572
  • ENST00000535600
  • ENSP00000442470
  • ENST00000541022
  • ENSP00000441230
  • ENST00000541716
  • ENSP00000437729

Symbol
  • P2X7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
disease
0.8
phenotype
0.68
biological term
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1263.02   (req: < 5)
Gene RIFs: 482   (req: <= 3)
Antibodies: 368   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1263.02   (req: >= 5)
Gene RIFs: 482   (req: > 3)
Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 77
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2970
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1