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Tchem
P2RX7
P2X purinoceptor 7

Protein Summary
Description
Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206). The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, J ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328963
  • ENSP00000330696
  • ENSG00000089041
  • ENST00000535250
  • ENSP00000442572
  • ENST00000535600
  • ENSP00000442470
  • ENST00000541022
  • ENSP00000441230
  • ENST00000541716
  • ENSP00000437729

Symbol
  • P2X7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
disease
0.8
phenotype
0.68
biological term
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
View Data
 GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1174.01   (req: < 5)
View Publications
Gene RIFs: 353   (req: <= 3)
View Gene RIFs
Antibodies: 368   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1174.01   (req: >= 5)
Gene RIFs: 353   (req: > 3)
Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 77
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2078
Explore Active Ligands
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Explore Approved Drugs
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
EFO_0004458
1
2
2
90.3
Items per page:
1 – 1 of 1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
EFO_0004458
2
90.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
purinergic receptor P2X 7
699455
Mouse
purinergic receptor P2X, ligand-gated ion channel, 7
MGI:1339957
18439
Rat
purinergic receptor P2X 7
RGD:3241
29665
Dog
purinergic receptor P2X 7
VGNC:44212
448778
Horse
purinergic receptor P2X 7
VGNC:21108
100058464
Species
Name
OMA
EggNOG
Inparanoid
Macaque
purinergic receptor P2X 7
Mouse
purinergic receptor P2X, ligand-gated ion channel, 7
Rat
purinergic receptor P2X 7
Dog
purinergic receptor P2X 7
Horse
purinergic receptor P2X 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q99572-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Elevation of cytosolic Ca2+ levels (R-HSA-139853)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elevation of cytosolic Ca2+ levels
16 targets
R-HSA-139853
Reactome
Hemostasis
666 targets
R-HSA-109582
Reactome
Immune System
2246 targets
R-HSA-168256
Reactome
Inflammasomes
20 targets
R-HSA-622312
Reactome
Innate Immune System
1188 targets
R-HSA-168249
Name
Explore in Pharos
Explore in Source
Elevation of cytosolic Ca2+ levels
16 targets
R-HSA-139853
Hemostasis
666 targets
R-HSA-109582
Immune System
2246 targets
R-HSA-168256
Inflammasomes
20 targets
R-HSA-622312
Innate Immune System
1188 targets
R-HSA-168249
Gene Ontology Terms (90)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
extracellularly ATP-gated cation channel activity
Inferred from Direct Assay (IDA)
BHF-UCL
purinergic nucleotide receptor activity
Inferred from Direct Assay (IDA)
BHF-UCL
ATP-gated ion channel activity
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
lipopolysaccharide binding
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
signaling receptor binding
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
protein homodimerization activity
Non-traceable Author Statement (NAS)
BHF-UCL
ATP binding
Inferred by Curator (IC)
BHF-UCL
Protein-Protein Interactions (95)
1 – 10 of 95
PANX1
Tbio
Family: IC
Novelty: 0.00159814
Score: 0.992
Data Source: Reactome,STRINGDB
P2RX4
Tchem
Family: IC
Novelty: 0.00242958
Score: 0.94
Data Source: STRINGDB
P2RX5
Tchem
Family: IC
Novelty: 0.01591178
Score: 0.936
Data Source: STRINGDB
P2RX1
Tchem
Family: IC
Novelty: 0.00286826
Score: 0.934
Data Source: STRINGDB
P2RX2
Tchem
Family: IC
Novelty: 0.00241146
Score: 0.919
Data Source: STRINGDB
P2RX6
Tchem
Family: IC
Novelty: 0.02091945
Score: 0.916
Data Source: STRINGDB
P2RX3
Tchem
Family: IC
Novelty: 0.00203167
Score: 0.91
Data Source: STRINGDB
NLRP3
Tchem
Novelty: 0.00043957
Score: 0.836
Data Source: STRINGDB
P2RY2
Tclin
Family: GPCR
Novelty: 0.00220741
Score: 0.8
Data Source: STRINGDB
CASP1
Tchem
Family: Enzyme
Novelty: 0.00034643
Score: 0.775
Data Source: STRINGDB
Publication Statistics
PubMed Score  1174.01

PubMed score by year
PubTator Score  895.28

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
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