Protein Summary
Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206). The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, J ...more
- ENST00000328963
- ENSP00000330696
- ENSG00000089041
- ENST00000535250
- ENSP00000442572
- ENST00000535600
- ENSP00000442470
- ENST00000541022
- ENSP00000441230
- ENST00000541716
- ENSP00000437729
- P2X7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
molecular function | 1 | ||
disease | 0.8 | ||
phenotype | 0.68 | ||
biological term | 0.66 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1223.2 (req: < 5)
Gene RIFs: 353 (req: <= 3)
Antibodies: 368 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1223.2 (req: >= 5)
Gene RIFs: 353 (req: > 3)
Antibodies: 368 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 77
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2966
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
1 – 2 of 2
Active Ligands (2966)
1 – 10 of 2966
Protein-Protein Interactions (95)
1 – 10 of 95
PANX1
Family: IC
Novelty: 0.00159814
Score: 0.992
Data Source: Reactome,STRINGDB
P2RX4
Family: IC
Novelty: 0.00242958
Score: 0.94
Data Source: STRINGDB
P2RX5
Family: IC
Novelty: 0.01591178
Score: 0.936
Data Source: STRINGDB
P2RX1
Family: IC
Novelty: 0.00286826
Score: 0.934
Data Source: STRINGDB
P2RX2
Family: IC
Novelty: 0.00241146
Score: 0.919
Data Source: STRINGDB
P2RX6
Family: IC
Novelty: 0.02091945
Score: 0.916
Data Source: STRINGDB
P2RX3
Family: IC
Novelty: 0.00203167
Score: 0.91
Data Source: STRINGDB
NLRP3
Novelty: 0.00043957
Score: 0.836
Data Source: STRINGDB
P2RY2
Family: GPCR
Novelty: 0.00220741
Score: 0.8
Data Source: STRINGDB
CASP1
Family: Enzyme
Novelty: 0.00034643
Score: 0.775
Data Source: STRINGDB
Pathways (12)
Reactome (9)
KEGG (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 9
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Elevation of cytosolic Ca2+ levels | ||||
Reactome | Hemostasis | ||||
Reactome | Immune System | ||||
Reactome | Inflammasomes | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Elevation of cytosolic Ca2+ levels | ||||
Hemostasis | ||||
Immune System | ||||
Inflammasomes | ||||
Innate Immune System | ||||
Gene Ontology Terms (90)
Functions (7)
Components (13)
Processes (70)
Items per page:
10
1 – 7 of 7
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Inferred by Curator (IC) | BHF-UCL | |||
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 3 | 24 | 25 | 98.6 | |||||
serum gamma-glutamyl transferase measurement | 3 | 14 | 14 | 98.5 | |||||
IGF-1 measurement | 1 | 2 | 2 | 83.8 | |||||
hemoglobin measurement | 1 | 1 | 1 | 76.1 | |||||
sex hormone-binding globulin measurement | 2 | 1 | 2 | 74.4 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 25 | 98.6 | |||||
serum gamma-glutamyl transferase measurement | 14 | 98.5 | |||||
IGF-1 measurement | 2 | 83.8 | |||||
hemoglobin measurement | 1 | 76.1 | |||||
sex hormone-binding globulin measurement | 2 | 74.4 | |||||
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UniProt Keyword
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GWAS Trait
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Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | purinergic receptor P2X 7 | 699455 | ||||||
Mouse | MGI:1339957 | 18439 | ||||||
Rat | RGD:3241 | 29665 | ||||||
Dog | purinergic receptor P2X 7 | VGNC:44212 | 448778 | |||||
Horse | purinergic receptor P2X 7 | VGNC:21108 | 100058464 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | purinergic receptor P2X 7 | |||||
Mouse | ||||||
Rat | ||||||
Dog | purinergic receptor P2X 7 | |||||
Horse | purinergic receptor P2X 7 | |||||
Publication Statistics
PubMed Score 1223.20
PubMed score by year
PubTator Score 895.28
PubTator score by year
Patents
Patents by year