Tchem P2RX7 P2X purinoceptor 7

Protein Classes

DTO Classes

Protein / Ion Channel / Atp-gated P2x Receptor Cation Channel (P2x Receptor) Family / P2x Purinoceptor 7

Protein Summary

Description

Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206). The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• Q99572
• A8K2Z0
• E7EMK6
• F5H6P2
• F5H7E8
• F8W951
• O14991
• Q4VKH8
• Q4VKH9
• Q4VKI0
• Q4VKI1
• Q4VKI2
• Q4VKI3
• Q4VKI4
• Q7Z771
• Q96EV7
• P2X7

Gene Name

• P2RX7

Ensembl ID

• ENST00000328963
• ENSP00000330696
• ENSG00000089041
• ENST00000535250
• ENSP00000442572
• ENST00000535600
• ENSP00000442470
• ENST00000541022
• ENSP00000441230
• ENST00000541716
• ENSP00000437729

Symbol

• P2X7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	1
disease	0.8
phenotype	0.68
biological term	0.66

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1073.38   (req: < 5)

Gene RIFs: 353   (req: <= 3)

Antibodies: 368   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1073.38   (req: >= 5)

Gene RIFs: 353   (req: > 3)

Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 77

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2078

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

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1 – 1 of 1

adenosine triphosphate

P2RX7Tchem IC

EC50: 3.1099999

Active Ligands (2078)

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1 – 10 of 2078

CHEMBL10

P2RX7Tchem IC

IC50: 5.3

CHEMBL28324

P2RX7Tchem IC

IC50: 7.9

CHEMBL3963084

P2RX7Tchem IC

IC50: 7.64

CHEMBL3674055

P2RX7Tchem IC

Ki: 8.02

CHEMBL3663242

P2RX7Tchem IC

Ki: 8.8

CHEMBL3663316

P2RX7Tchem IC

Ki: 8.7

CHEMBL3663239

P2RX7Tchem IC

Ki: 8.85

CHEMBL3697516

P2RX7Tchem IC

Ki: 8

CHEMBL3674136

P2RX7Tchem IC

Ki: 7.7

CHEMBL3663294

P2RX7Tchem IC

Ki: 8.89

Pathways (12)

Reactome (9)

KEGG (3)

Elevation of cytosolic Ca2+ levels (R-HSA-139853)

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Items per page:

5

1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Elevation of cytosolic Ca2+ levels	16 targets	R-HSA-139853
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Inflammasomes	20 targets	R-HSA-622312
Reactome	Innate Immune System	1188 targets	R-HSA-168249

Name	Explore in Pharos	Explore in Source
Elevation of cytosolic Ca2+ levels	16 targets	R-HSA-139853
Hemostasis	666 targets	R-HSA-109582
Immune System	2246 targets	R-HSA-168256
Inflammasomes	20 targets	R-HSA-622312
Innate Immune System	1188 targets	R-HSA-168249

Gene Ontology Terms (90)

Functions (7)

Components (13)

Processes (70)

Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
extracellularly ATP-gated cation channel activity	Inferred from Direct Assay (IDA)	BHF-UCL
purinergic nucleotide receptor activity	Inferred from Direct Assay (IDA)	BHF-UCL
ATP-gated ion channel activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
lipopolysaccharide binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
signaling receptor binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
protein homodimerization activity	Non-traceable Author Statement (NAS)	BHF-UCL
ATP binding	Inferred by Curator (IC)	BHF-UCL

Protein-Protein Interactions (95)

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1 – 10 of 95

• See Interactions on String-DB

PANX1

Tbio

Family: IC

Novelty: 0.00209499

Score: 0.992

Data Source: Reactome,STRINGDB

P2RX4

Tchem

Family: IC

Novelty: 0.00292374

Score: 0.94

Data Source: STRINGDB

P2RX5

Tchem

Family: IC

Novelty: 0.02646451

Score: 0.936

Data Source: STRINGDB

P2RX1

Tchem

Family: IC

Novelty: 0.00376724

Score: 0.934

Data Source: STRINGDB

P2RX2

Tchem

Family: IC

Novelty: 0.00308345

Score: 0.919

Data Source: STRINGDB

P2RX6

Tchem

Family: IC

Novelty: 0.03263451

Score: 0.916

Data Source: STRINGDB

P2RX3

Tchem

Family: IC

Novelty: 0.00216381

Score: 0.91

Data Source: STRINGDB

NLRP3

Tchem

Novelty: 0.00042021

Score: 0.836

Data Source: STRINGDB

P2RY2

Tclin

Family: GPCR

Novelty: 0.00178586

Score: 0.8

Data Source: STRINGDB

CASP1

Tchem

Family: Enzyme

Novelty: 0.00043112

Score: 0.775

Data Source: STRINGDB

Publication Statistics

PubMed Score  1073.38

PubMed score by year

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PubTator Score  895.28

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Sequence

MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAE

1-70

VKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWM

70-140

DPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILP

140-210

GLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDD

210-280

KTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVF

280-350

IDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS

350-420

LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPES

420-490

HRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGS

490-560

QDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY

560-595

MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY

Find similar targets by:

Uniprot Keyword

ADP-ribosylation
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Lipoprotein