Protein Classes
Protein Summary
Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin. The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
- ENST00000337233
- ENSP00000336607
- ENSG00000135124
- ENST00000359949
- ENSP00000353032
- ENST00000542067
- ENSP00000438329
- P2X4
- P2X4R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 1 | ||
biological process | 0.96 | ||
cellular component | 0.88 | ||
transcription factor perturbation | 0.84 | ||
histone modification site profile | 0.75 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 462.4 (req: < 5)
Gene RIFs: 53 (req: <= 3)
Antibodies: 240 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 462.4 (req: >= 5)
Gene RIFs: 53 (req: > 3)
Antibodies: 240 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 47
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 6
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
Active Ligands (6)
1 – 6 of 6
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body mass index | 2 | 1 | 2 | 79.4 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body mass index | 2 | 79.4 | |||||
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | purinergic receptor P2X 4 | VGNC:8487 | 452319 | |||||
Macaque | purinergic receptor P2X 4 | 702536 | ||||||
Mouse | MGI:1338859 | 18438 | ||||||
Rat | RGD:62073 | 29659 | ||||||
Dog | purinergic receptor P2X 4 | VGNC:44210 | 448783 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | purinergic receptor P2X 4 | |||||
Macaque | purinergic receptor P2X 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | purinergic receptor P2X 4 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (6)
Reactome (4)
KEGG (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Elevation of cytosolic Ca2+ levels | ||||
Reactome | Hemostasis | ||||
Reactome | Platelet calcium homeostasis | ||||
Reactome | Platelet homeostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Elevation of cytosolic Ca2+ levels | ||||
Hemostasis | ||||
Platelet calcium homeostasis | ||||
Platelet homeostasis | ||||
Gene Ontology Terms (61)
Functions (10)
Components (14)
Processes (37)
Items per page:
10
1 – 10 of 10
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Inferred by Curator (IC) | BHF-UCL | |||
Protein-Protein Interactions (84)
1 – 10 of 84
CYBC1
Novelty: 0.72567331
p_int: 0.999979184
p_ni: 0.000020769
p_wrong: 4.7e-8
Score: 0.235
Data Source: BioPlex,STRINGDB
B3GALT5
Family: Enzyme
Novelty: 0.04158039
p_int: 0.999968548
p_ni: 0.000031318
p_wrong: 1.34e-7
Data Source: BioPlex
SPPL2B
Family: Enzyme
Novelty: 0.0274774
p_int: 0.999903309
p_ni: 0.000096569
p_wrong: 1.22e-7
Data Source: BioPlex
FAM20B
Family: Enzyme
Novelty: 0.07347685
p_int: 0.999499577
p_ni: 0.000500417
p_wrong: 6e-9
Score: 0.518
Data Source: BioPlex,STRINGDB
PIGH
Family: Enzyme
Novelty: 0.0584561
p_int: 0.999040372
p_ni: 0.00084138
p_wrong: 0.000118248
Score: 0.235
Data Source: BioPlex,STRINGDB
CSGALNACT2
Family: Enzyme
Novelty: 0.0770692
p_int: 0.998733181
p_ni: 0.00036208
p_wrong: 0.000904739
Data Source: BioPlex
EIF2B3
Novelty: 0.04963646
p_int: 0.996952978
p_ni: 0.003047022
Data Source: BioPlex
EIF2B5
Novelty: 0.0102209
p_int: 0.993729264
p_ni: 0.006270736
Score: 0.196
Data Source: BioPlex,STRINGDB
TNPO3
Novelty: 0.01709028
p_int: 0.968982129
p_ni: 0.031017871
Data Source: BioPlex
EIF2B4
Novelty: 0.05080792
p_int: 0.958370796
p_ni: 0.041629204
Data Source: BioPlex
Publication Statistics
PubMed Score 462.40
PubMed score by year
PubTator Score 162.68
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword