Tbio PKP4 Plakophilin-4

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Intermediate Filament / Intermediate Filament Binding Protein / Plakophilin-4

Protein Summary

Description

Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]

Uniprot Accession IDs

• Q99569
• Q86W91

Gene Name

• PKP4

Ensembl ID

• ENST00000389757
• ENSP00000374407
• ENSG00000144283
• ENST00000389759
• ENSP00000374409

Symbol

• p0071

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.96
kinase perturbation	0.95
transcription factor	0.93
transcription factor perturbation	0.91
drug perturbation	0.87

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.16   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 152   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.16   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (5)

Reactome (3)

PathwayCommons (2)

Developmental Biology (R-HSA-1266738)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Formation of the cornified envelope	75 targets	R-HSA-6809371
Reactome	Keratinization	217 targets	R-HSA-6805567

Name	Explore in Pharos	Explore in Source
Developmental Biology	1055 targets	R-HSA-1266738
Formation of the cornified envelope	75 targets	R-HSA-6809371
Keratinization	217 targets	R-HSA-6805567

Gene Ontology Terms (25)

Functions (1)

Components (16)

Processes (8)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
cadherin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (108)

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1 – 10 of 108

• See Interactions on String-DB

CDH8

Tbio

Novelty: 0.05007376

p_int: 0.999999974

p_ni: 2.6e-8

Score: 0.38

Data Source: BioPlex,STRINGDB

CDH5

Tbio

Novelty: 0.00096405

p_int: 0.999998964

p_ni: 0.000001035

p_wrong: 1e-9

Score: 0.628

Data Source: BioPlex,STRINGDB

CTNNA3

Tbio

Novelty: 0.02196369

p_int: 0.999989104

p_ni: 0.000010896

Score: 0.433

Data Source: BioPlex,STRINGDB

CLEC11A

Tbio

Novelty: 0.01702243

p_int: 0.999921116

p_ni: 0.000078884

Score: 0.187

Data Source: BioPlex,STRINGDB

APBA3

Tbio

Novelty: 0.06087545

p_int: 0.999898299

p_ni: 0.000101701

Score: 0.175

Data Source: BioPlex,STRINGDB

TAX1BP3

Tbio

Novelty: 0.01762102

p_int: 0.999850756

p_ni: 0.000149244

Data Source: BioPlex

PTGER3

Tclin

Family: GPCR

Novelty: 0.00155764

p_int: 0.989764893

p_ni: 0.010235103

p_wrong: 4e-9

Score: 0.179

Data Source: BioPlex,STRINGDB

ABTB2

Tdark

Novelty: 3.6

p_int: 0.983262135

p_ni: 0.016737865

Data Source: BioPlex

TACR3

Tchem

Family: GPCR

Novelty: 0.00322406

p_int: 0.975215999

p_ni: 0.024784001

Data Source: BioPlex

TMEM52B

Tdark

Novelty: 1

p_int: 0.956926137

p_ni: 0.043065907

p_wrong: 0.000007957

Data Source: BioPlex

Publication Statistics

PubMed Score  21.16

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PubTator Score  22.62

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Alternative splicing
Cell adhesion
Cell junction
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