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Tbio
NUP88
Nuclear pore complex protein Nup88

Protein Summary
Description
Essential component of nuclear pore complex. The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000573584
  • ENSP00000458954
  • ENSG00000108559
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
pathway
0.99
disease perturbation
0.96
histone modification site profile
0.88
transcription factor binding site profile
0.83


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.22   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.22   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (178)
NUP62CL
Tdark
Novelty:  2.93223607
p_int:  0.999994211
p_ni:  0.000003482
p_wrong:  0.000002308
Score:  0.741
Data Source:  BioPlex,STRINGDB
NUP214
Tbio
Novelty:  0.00924336
p_int:  0.999968251
p_ni:  0.000031749
Score:  0.999
Data Source:  BioPlex,STRINGDB
TRIM62
Tbio
Family:  Enzyme
Novelty:  0.12565021
p_int:  0.999930949
p_ni:  0.000068894
p_wrong:  1.58e-7
Score:  0.209
Data Source:  BioPlex,STRINGDB
NUP62
Tbio
Novelty:  0.01432724
p_int:  0.99668382
p_ni:  0.00331618
Score:  0.999
Data Source:  BioPlex,STRINGDB
NUP98
Tbio
Family:  Enzyme
Novelty:  0.00401452
p_int:  0.995877733
p_ni:  0.004122267
Score:  0.931
Data Source:  BioPlex,STRINGDB
DDX19A
Tdark
Family:  Enzyme
Novelty:  0.54074082
p_int:  0.983006001
p_ni:  0.016993999
Score:  0.882
Data Source:  BioPlex,STRINGDB
COG6
Tbio
Novelty:  0.02874093
p_int:  0.975864878
p_ni:  0.024135122
Data Source:  BioPlex
G3BP2
Tbio
Family:  Enzyme
Novelty:  0.04786241
p_int:  0.812318834
p_ni:  0.187681166
Score:  0.774
Data Source:  BioPlex,STRINGDB
NUP107
Tbio
Novelty:  0.01994155
Score:  0.996
Data Source:  STRINGDB
NUP153
Tbio
Novelty:  0.00696568
Score:  0.994
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (71)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 68
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cell Cycle
Cell Cycle, Mitotic
Cellular response to heat stress
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
2
2
86.1
body mass index
8
3
9
85.2
myeloid white cell count
1
1
1
78.1
leukocyte count
2
2
2
78
neutrophil count
2
1
2
64.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
86.1
body mass index
9
85.2
myeloid white cell count
1
78.1
leukocyte count
2
78
neutrophil count
2
64.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 88
VGNC:9489
748596
Macaque
nucleoporin 88
711734
Mouse
MGI:104900
19069
Rat
RGD:620182
113929
Dog
nucleoporin 88
VGNC:44061
607268
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 88
Macaque
nucleoporin 88
Mouse
Rat
Dog
nucleoporin 88
Publication Statistics
PubMed Score 40.22
PubMed score by year
PubTator Score 30.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title