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Tchem
MAP3K14
Mitogen-activated protein kinase kinase kinase 14

Protein Summary
Description
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner. This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344686
  • ENSP00000478552
  • ENSG00000006062
  • ENST00000376926
  • ENSP00000482657
  • ENST00000648527
  • ENSP00000497704

Symbol
  • NIK
  • HS
  • NIK
  • HSNIK
  • FTDCR1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
0.98
transcription factor binding site profile
0.88
biological process
0.79
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.23   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 318   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.23   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 318   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 491
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (491)
1 – 10 of 491
NIK SMI1
Rendered image for NIK SMI1
CHEMBL4113471
Rendered image for CHEMBL4113471
CHEMBL4524153
Rendered image for CHEMBL4524153
CHEMBL3957252
Rendered image for CHEMBL3957252
US9034866, 8
Rendered image for US9034866, 8
CHEMBL4073390
Rendered image for CHEMBL4073390
CHEMBL3692392
Rendered image for CHEMBL3692392
CHEMBL2334589
Rendered image for CHEMBL2334589
US9034866, 227
Rendered image for US9034866, 227
Protein-Protein Interactions (174)
1 – 10 of 174
CHUK
Tchem
Family:  Kinase
Novelty:  0.00151532
p_int:  0.999999372
p_ni:  6.28e-7
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
IKBKB
Tchem
Family:  Kinase
Novelty:  0.00090202
p_int:  0.999999019
p_ni:  9.8e-7
p_wrong:  1e-9
Score:  0.993
Data Source:  BioPlex,STRINGDB
IKBKG
Tbio
Family:  Kinase
Novelty:  0.0006149
p_int:  0.999994493
p_ni:  0.000005485
p_wrong:  2.2e-8
Score:  0.99
Data Source:  BioPlex,STRINGDB
TRAF3
Tbio
Novelty:  0.0022525
p_int:  0.999910945
p_ni:  0.000089004
p_wrong:  5.1e-8
Score:  0.971
Data Source:  BioPlex,Reactome,STRINGDB
HSP90AA5P
Tdark
p_int:  0.954065731
p_ni:  0.04593426
p_wrong:  9e-9
Data Source:  BioPlex
NAV1
Tbio
Novelty:  0.00444608
p_int:  0.83075281
p_ni:  0.165095924
p_wrong:  0.004151266
Score:  0.345
Data Source:  BioPlex,STRINGDB
NFKB2
Tchem
Family:  TF
Novelty:  0.00366074
Score:  0.974
Data Source:  Reactome,STRINGDB
BIRC3
Tchem
Novelty:  0.00189613
Score:  0.967
Data Source:  Reactome,STRINGDB
BIRC2
Tchem
Novelty:  0.00199701
Score:  0.963
Data Source:  Reactome,STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.957
Data Source:  STRINGDB
Pathways (59)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
C-type lectin receptors (CLRs)
Reactome
CD28 co-stimulation
Reactome
CD28 dependent PI3K/Akt signaling
Reactome
CLEC7A (Dectin-1) signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
C-type lectin receptors (CLRs)
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CLEC7A (Dectin-1) signaling
Gene Ontology Terms (21)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
MGI
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
2
4
2
7.2
80.4
heel bone mineral density
1
1
1
77.4
5
3
0
1
71.4
myeloid white cell count
1
1
1
67.1
platelet crit
1
1
1
66.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
2
7.2
80.4
heel bone mineral density
1
77.4
0
1
71.4
myeloid white cell count
1
67.1
platelet crit
1
66.8
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
mitogen-activated protein kinase kinase kinase 14
716258
Mouse
MGI:1858204
53859
Rat
RGD:1310487
360640
Dog
mitogen-activated protein kinase kinase kinase 14
VGNC:42970
490926
Horse
mitogen-activated protein kinase kinase kinase 14
VGNC:19933
100050140
Species
Name
OMA
EggNOG
Inparanoid
Macaque
mitogen-activated protein kinase kinase kinase 14
Mouse
Rat
Dog
mitogen-activated protein kinase kinase kinase 14
Horse
mitogen-activated protein kinase kinase kinase 14
Publication Statistics
PubMed Score 29.23
PubMed score by year
PubTator Score 175.27
PubTator score by year