You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MTERF1
Transcription termination factor 1, mitochondrial

Protein Summary
Description
Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand. This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the thre ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351870
  • ENSP00000248643
  • ENSG00000127989

Symbol
  • MTERF
  • MTERF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
cell type or tissue
0.78
transcription factor binding site profile
0.73
cellular component
0.63
cell line
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.88   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.88   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
36.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
36.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial transcription termination factor 1
VGNC:4436
472439
Macaque
mitochondrial transcription termination factor 1
703725
Mouse
MGI:1918240
545725
Mouse
MGI:3704243
208595
Rat
RGD:621318
85261
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial transcription termination factor 1
Macaque
mitochondrial transcription termination factor 1
Mouse
Mouse
Rat
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99551-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Mitochondrial biogenesis
Reactome
Mitochondrial transcription termination
Reactome
Organelle biogenesis and maintenance
Reactome
Transcription from mitochondrial promoters
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Mitochondrial biogenesis
Mitochondrial transcription termination
Organelle biogenesis and maintenance
Transcription from mitochondrial promoters
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (65)
1 – 10 of 65
PNPO
Tchem
Family:  Enzyme
Novelty:  0.00919993
p_int:  0.999999998
p_ni:  2e-9
Score:  0.485
Data Source:  BioPlex,STRINGDB
EIF1AD
Tdark
Novelty:  0.23915521
p_int:  0.999999714
p_ni:  1e-9
p_wrong:  2.85e-7
Data Source:  BioPlex
MPV17
Tbio
Novelty:  0.01969556
Score:  0.905
Data Source:  STRINGDB
GABPA
Tbio
Family:  TF
Novelty:  0.01731451
Score:  0.9
Data Source:  STRINGDB
MTERF3
Tdark
Novelty:  0.06316581
Score:  0.849
Data Source:  STRINGDB
MTERF4
Tbio
Novelty:  0.17764705
Score:  0.832
Data Source:  STRINGDB
POLRMT
Tbio
Family:  Enzyme
Novelty:  0.01398067
Score:  0.807
Data Source:  STRINGDB
TFB2M
Tbio
Family:  Enzyme
Novelty:  0.02345237
Score:  0.777
Data Source:  STRINGDB
TFAM
Tbio
Family:  TF
Novelty:  0.00131608
Score:  0.748
Data Source:  STRINGDB
MGME1
Tbio
Family:  Enzyme
Novelty:  0.05284418
Score:  0.739
Data Source:  STRINGDB
Publication Statistics
PubMed Score  122.88

PubMed score by year
PubTator Score  16.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: