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Tbio
MPHOSPH8
M-phase phosphoprotein 8

Protein Summary
Description
Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361479
  • ENSP00000355388
  • ENSG00000196199

Symbol
  • MPP8
  • TWA3
  • mpp8
  • HSMPP8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
protein domain
0.85
ligand (protein) perturbation
0.83
cellular component
0.77
transcription factor binding site profile
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.68   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.68   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
M-phase phosphoprotein 8
VGNC:5079
467217
Mouse
MGI:1922589
75339
Horse
M-phase phosphoprotein 8
VGNC:20284
100053303
Cow
M-phase phosphoprotein 8
VGNC:31575
507091
Pig
M-phase phosphoprotein 8
100519866
Species
Name
OMA
EggNOG
Inparanoid
Chimp
M-phase phosphoprotein 8
Mouse
Horse
M-phase phosphoprotein 8
Cow
M-phase phosphoprotein 8
Pig
M-phase phosphoprotein 8
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99549-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (105)
1 – 10 of 105
ZNF597
Tbio
Family: TF
Novelty: 0.04420398
p_int: 0.999999997
p_ni: 3e-9
Score: 0.583
Data Source: BioPlex,STRINGDB
ERH
Tbio
Novelty: 0.00711649
p_int: 0.999999369
p_ni: 6.2e-7
p_wrong: 1.1e-8
Data Source: BioPlex
DAXX
Tbio
Novelty: 0.00348585
p_int: 0.999993709
p_ni: 0.00000629
p_wrong: 1e-9
Score: 0.16
Data Source: BioPlex,STRINGDB
ESAM
Tbio
Novelty: 0.00462452
p_int: 0.986520347
p_ni: 0.000389102
p_wrong: 0.01309055
Score: 0.54
Data Source: BioPlex,STRINGDB
HIST1H4A
Tbio
Novelty: 0.00279614
Score: 0.941
Data Source: STRINGDB
RANBP9
Tbio
Novelty: 0.02182372
Score: 0.94
Data Source: STRINGDB
HIST1H3A
Tbio
Novelty: 0.00991842
Score: 0.939
Data Source: STRINGDB
H3F3A
Tbio
Novelty: 0.00508186
Score: 0.935
Data Source: STRINGDB
HIST3H3
Tbio
Novelty: 0.04915012
Score: 0.935
Data Source: STRINGDB
CENPA
Tbio
Novelty: 0.00154245
Score: 0.935
Data Source: STRINGDB
Publication Statistics
PubMed Score  21.68

PubMed score by year
PubTator Score  14.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer