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Tbio
MPHOSPH6
M-phase phosphoprotein 6

Protein Summary
Description
RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258169
  • ENSP00000258169
  • ENSG00000135698

Symbol
  • MPP6
  • MPP
  • MPP6
  • MPP-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
virus perturbation
0.79
transcription factor binding site profile
0.72
cellular component
0.66
disease perturbation
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.44   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.44   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
1
1
43.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
43.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
M-phase phosphoprotein 6
VGNC:5842
454270
Macaque
M-phase phosphoprotein 6
714335
Mouse
MGI:1915783
68533
Rat
RGD:1591222
686999
Dog
M-phase phosphoprotein 6
VGNC:43336
479632
Species
Name
OMA
EggNOG
Inparanoid
Chimp
M-phase phosphoprotein 6
Macaque
M-phase phosphoprotein 6
Mouse
Rat
Dog
M-phase phosphoprotein 6
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99547-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (157)
1 – 10 of 157
ZFC3H1
Tbio
Novelty: 0.17313739
p_int: 0.999999922
p_ni: 7.7e-8
Score: 0.931
Data Source: BioPlex,STRINGDB
C1D
Tbio
Novelty: 0.00997109
p_int: 0.999995418
p_ni: 0.000004583
Score: 0.986
Data Source: BioPlex,Reactome,STRINGDB
WDR3
Tbio
Novelty: 0.15410886
p_int: 0.999993834
p_ni: 0.000006166
Score: 0.904
Data Source: BioPlex,STRINGDB
ZNF106
Tbio
Novelty: 0.17021565
p_int: 0.999984523
p_ni: 0.000015477
Data Source: BioPlex
EXOSC3
Tbio
Novelty: 0.03072164
p_int: 0.999970761
p_ni: 0.00002924
Score: 0.999
Data Source: BioPlex,STRINGDB
PWP2
Tbio
Novelty: 0.04910741
p_int: 0.999968047
p_ni: 0.000031953
Score: 0.904
Data Source: BioPlex,STRINGDB
EXOSC1
Tbio
Novelty: 0.01386842
p_int: 0.99993668
p_ni: 0.00006332
Score: 0.999
Data Source: BioPlex,STRINGDB
RBM7
Tbio
Novelty: 0.07482689
p_int: 0.999933258
p_ni: 0.000066743
Data Source: BioPlex
EXOSC4
Tbio
Family: Enzyme
Novelty: 0.00798796
p_int: 0.999916014
p_ni: 0.000083986
Score: 0.998
Data Source: BioPlex,STRINGDB
EXOSC10
Tbio
Novelty: 0.00335571
p_int: 0.999872872
p_ni: 0.000127128
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  5.44

PubMed score by year
PubTator Score  19.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer