Tbio MPHOSPH6 M-phase phosphoprotein 6

Protein Summary

Description

RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D.

Uniprot Accession IDs

• Q99547
• B2RAF0

Gene Name

• MPHOSPH6

Ensembl ID

• ENST00000258169
• ENSP00000258169
• ENSG00000135698

Symbol

• MPP6
• MPP
• MPP6
• MPP-6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.85
virus perturbation	0.79
transcription factor binding site profile	0.72
cellular component	0.66
disease perturbation	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.15   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 161   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.15   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0