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Tbio
DNAJC2
DnaJ homolog subfamily C member 2

Protein Summary
Description
Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'. This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of for ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249270
  • ENSP00000249270
  • ENSG00000105821
  • ENST00000379263
  • ENSP00000368565

Symbol
  • MPHOSPH11
  • MPP11
  • ZRF1
  • ZRF1
  • ZUO1
  • MPP11
  • MPHOSPH11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
kinase perturbation
0.84
transcription factor perturbation
0.84
protein domain
0.73
transcription factor binding site profile
0.73


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.08   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.08   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (149)
HSPA14
Tbio
Novelty:  0.01714625
p_int:  0.999999842
p_ni:  2.9e-8
p_wrong:  1.29e-7
Score:  0.993
Data Source:  BioPlex,STRINGDB
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.999683733
p_ni:  0.000299785
p_wrong:  0.000016482
Score:  0.233
Data Source:  BioPlex,STRINGDB
USP47
Tchem
Family:  Enzyme
Novelty:  0.07579226
p_int:  0.855188934
p_ni:  0.000077251
p_wrong:  0.144733814
Score:  0.218
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
Score:  0.985
Data Source:  STRINGDB
HSPA4
Tbio
Novelty:  0.00009122
Score:  0.981
Data Source:  STRINGDB
HSPA4L
Tbio
Novelty:  0.05591399
Score:  0.974
Data Source:  STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
Score:  0.973
Data Source:  STRINGDB
HSPA9
Tchem
Novelty:  0.00235171
Score:  0.96
Data Source:  STRINGDB
HSPA1A
Tchem
Novelty:  0.00069195
Score:  0.957
Data Source:  Reactome,STRINGDB
HSPA1B
Tbio
Novelty:  0.01429214
Score:  0.954
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cellular response to heat stress (R-HSA-3371556)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Regulation of HSF1-mediated heat shock response
Name
Explore in Pharos
Explore in Source
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Regulation of HSF1-mediated heat shock response
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
0
1
74.3
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
0
1
74.3
1
54.4
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C2
VGNC:7376
743112
Macaque
DnaJ heat shock protein family (Hsp40) member C2
695890
Mouse
MGI:99470
22791
Rat
RGD:620524
116456
Dog
DnaJ heat shock protein family (Hsp40) member C2
VGNC:51863
483275
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C2
Macaque
DnaJ heat shock protein family (Hsp40) member C2
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member C2
Publication Statistics
PubMed Score 73.08
PubMed score by year
PubTator Score 21.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title