Tbio MMP19 Matrix metalloproteinase-19

Protein Summary

Description

Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

Uniprot Accession IDs

• Q99542
• B4E030
• O15278
• O95606
• Q99580
• MMP-19

Gene Name

• MMP19

Ensembl ID

• ENST00000322569
• ENSP00000313437
• ENSG00000123342
• ENST00000409200
• ENSP00000386625
• ENST00000552872
• ENSP00000446776

Symbol

• MMP18
• RASI
• CODA
• MMP18
• RASI-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
tissue sample	0.64
phenotype	0.62
microRNA	0.53
molecular function	0.53

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Matrix Metalloproteinase-19

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Matrix Metalloproteinase-19

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.32   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 452   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.32   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 452   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0