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Tbio
PLIN2
Perilipin-2

Protein Summary
Description
May be involved in development and maintenance of adipose tissue. The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276914
  • ENSP00000276914
  • ENSG00000147872

Symbol
  • ADFP
  • ADFP
  • ADRP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
small molecule perturbation
0.97
transcription factor perturbation
0.97
disease
0.92
PubMedID
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 551.61   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 837   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 551.61   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 837   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
2
1
79.8
mean platelet volume
2
2
2
77.8
1
1
0
1.1
59.8
testosterone measurement
3
3
3
59
platelet count
1
1
1
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
79.8
mean platelet volume
2
77.8
0
1.1
59.8
testosterone measurement
3
59
platelet count
1
56.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
perilipin 2
VGNC:4823
465012
Mouse
MGI:87920
11520
Rat
RGD:728889
298199
Dog
perilipin 2
VGNC:44691
100856329
Horse
perilipin 2
VGNC:21578
100052253
Species
Name
OMA
EggNOG
Inparanoid
Chimp
perilipin 2
Mouse
Rat
Dog
perilipin 2
Horse
perilipin 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q99541-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Chaperone Mediated Autophagy
Reactome
Lipophagy
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Autophagy
Chaperone Mediated Autophagy
Lipophagy
Metabolism
Metabolism of lipids
Gene Ontology Terms (11)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (143)
1 – 10 of 143
PPARA
Tclin
Family:  NR
Novelty:  0.00017403
Score:  0.951
Data Source:  STRINGDB
FABP1
Tchem
Novelty:  0.00192691
Score:  0.943
Data Source:  STRINGDB
RXRA
Tclin
Family:  NR
Novelty:  0.00244343
Score:  0.923
Data Source:  STRINGDB
ABHD5
Tbio
Family:  Enzyme
Novelty:  0.00806614
Score:  0.909
Data Source:  STRINGDB
NCOA1
Tchem
Family:  Epigenetic
Novelty:  0.00344663
Score:  0.906
Data Source:  STRINGDB
NCOA2
Tbio
Novelty:  0.00510052
Score:  0.904
Data Source:  STRINGDB
HELZ2
Tdark
Family:  Enzyme
Novelty:  0.1810765
Score:  0.902
Data Source:  STRINGDB
MED1
Tbio
Family:  Enzyme
Novelty:  0.00852082
Score:  0.902
Data Source:  STRINGDB
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
Score:  0.902
Data Source:  STRINGDB
CHD9
Tbio
Family:  Epigenetic
Novelty:  0.06234268
Score:  0.901
Data Source:  STRINGDB
Publication Statistics
PubMed Score  551.61

PubMed score by year
PubTator Score  297.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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