Tbio PLIN2 Perilipin-2

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Perilipin-2

DTO Classes

Protein / Transporter / Perilipin-2

Protein Summary

Description

May be involved in development and maintenance of adipose tissue. The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q99541
• Q9BSC3

Gene Name

• PLIN2

Ensembl ID

• ENST00000276914
• ENSP00000276914
• ENSG00000147872

Symbol

• ADFP
• ADFP
• ADRP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
small molecule perturbation	0.97
transcription factor perturbation	0.97
disease	0.92
PubMedID	0.91

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 435.48   (req: < 5)

Gene RIFs: 71   (req: <= 3)

Antibodies: 837   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 435.48   (req: >= 5)

Gene RIFs: 71   (req: > 3)

Antibodies: 837   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (13)

Reactome (8)

KEGG (1)

PathwayCommons (1)

WikiPathways (3)

Autophagy (R-HSA-9612973)

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Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Autophagy	109 targets	R-HSA-9612973
Reactome	Chaperone Mediated Autophagy	16 targets	R-HSA-9613829
Reactome	Lipophagy	9 targets	R-HSA-9613354
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833

Name	Explore in Pharos	Explore in Source
Autophagy	109 targets	R-HSA-9612973
Chaperone Mediated Autophagy	16 targets	R-HSA-9613829
Lipophagy	9 targets	R-HSA-9613354
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833

Gene Ontology Terms (11)

Components (6)

Processes (5)

Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
lipid droplet	Inferred from Direct Assay (IDA)	UniProtKB
endoplasmic reticulum	Traceable Author Statement (TAS)	ProtInc
extracellular region	Traceable Author Statement (TAS)	ProtInc
plasma membrane	Traceable Author Statement (TAS)	Reactome
cytosol	Inferred from Electronic Annotation (IEA)	Ensembl
nucleus	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (143)

Explore Interacting Targets

1 – 10 of 143

• See Interactions on String-DB

PPARA

Tclin

Family: NR

Novelty: 0.00026802

Score: 0.951

Data Source: STRINGDB

FABP1

Tchem

Novelty: 0.002508

Score: 0.943

Data Source: STRINGDB

RXRA

Tclin

Family: NR

Novelty: 0.00314166

Score: 0.923

Data Source: STRINGDB

ABHD5

Tbio

Family: Enzyme

Novelty: 0.00998736

Score: 0.909

Data Source: STRINGDB

NCOA1

Tchem

Family: Epigenetic

Novelty: 0.00427551

Score: 0.906

Data Source: STRINGDB

NCOA2

Tbio

Novelty: 0.00643607

Score: 0.904

Data Source: STRINGDB

CREBBP

Tchem

Family: Epigenetic

Novelty: 0.00127032

Score: 0.902

Data Source: STRINGDB

HELZ2

Tdark

Family: Enzyme

Novelty: 0.28753695

Score: 0.902

Data Source: STRINGDB

MED1

Tbio

Family: Enzyme

Novelty: 0.01259825

Score: 0.902

Data Source: STRINGDB

CHD9

Tbio

Family: Epigenetic

Novelty: 0.10573131

Score: 0.901

Data Source: STRINGDB

Publication Statistics

PubMed Score  435.48

PubMed score by year

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PubTator Score  297.89

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MASVAVDPQPSVVTRVVNLPLVSSTYDLMSSAYLSTKDQYPYLKSVCEMAENGVKTITSVAMTSALPIIQ

1-70

KLEPQIAVANTYACKGLDRIEERLPILNQPSTQIVANAKGAVTGAKDAVTTTVTGAKDSVASTITGVMDK

70-140

TKGAVTGSVEKTKSVVSGSINTVLGSRMMQLVSSGVENALTKSELLVEQYLPLTEEELEKEAKKVEGFDL

140-210

VQKPSYYVRLGSLSTKLHSRAYQQALSRVKEAKQKSQQTISQLHSTVHLIEFARKNVYSANQKIQDAQDK

210-280

LYLSWVEWKRSIGYDDTDESHCAEHIESRTLAIARNLTQQLQTTCHTLLSNIQGVPQNIQDQAKHMGVMA

280-350

GDIYSVFRNAASFKEVSDSLLTSSKGQLQKMKESLDDVMDYLVNNTPLNWLVGPFYPQLTESQNAQDQGA

350-420

EMDKSSQETQRSEHKTH

420-437

MASVAVDPQPSVVTRVVNLPLVSSTYDLMSSAYLSTKDQYPYLKSVCEMAENGVKTITSVAMTSALPIIQKLEPQIAVANTYACKGLDRIEERLPILNQPSTQIVANAKGAVTGAKDAVTTTVTGAKDSVASTITGVMDKTKGAVTGSVEKTKSVVSGSINTVLGSRMMQLVSSGVENALTKSELLVEQYLPLTEEELEKEAKKVEGFDLVQKPSYYVRLGSLSTKLHSRAYQQALSRVKEAKQKSQQTISQLHSTVHLIEFARKNVYSANQKIQDAQDKLYLSWVEWKRSIGYDDTDESHCAEHIESRTLAIARNLTQQLQTTCHTLLSNIQGVPQNIQDQAKHMGVMAGDIYSVFRNAASFKEVSDSLLTSSKGQLQKMKESLDDVMDYLVNNTPLNWLVGPFYPQLTESQNAQDQGAEMDKSSQETQRSEHKTH

Find similar targets by:

Uniprot Keyword

Acetylation
Complete proteome
Lipid droplet
Lipoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome