Protein Classes
Protein Summary
May be involved in development and maintenance of adipose tissue. The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]
- ENST00000276914
- ENSP00000276914
- ENSG00000147872
- ADFP
- ADFP
- ADRP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.97 | ||
small molecule perturbation | 0.97 | ||
transcription factor perturbation | 0.97 | ||
disease | 0.92 | ||
PubMedID | 0.91 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 551.61 (req: < 5)
Gene RIFs: 71 (req: <= 3)
Antibodies: 837 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 551.61 (req: >= 5)
Gene RIFs: 71 (req: > 3)
Antibodies: 837 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
3 | 3 | 2 | 1 | 79.8 | |||||
mean platelet volume | 2 | 2 | 2 | 77.8 | |||||
1 | 1 | 0 | 1.1 | 59.8 | |||||
testosterone measurement | 3 | 3 | 3 | 59 | |||||
platelet count | 1 | 1 | 1 | 56.4 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
2 | 1 | 79.8 | |||||
mean platelet volume | 2 | 77.8 | |||||
0 | 1.1 | 59.8 | |||||
testosterone measurement | 3 | 59 | |||||
platelet count | 1 | 56.4 | |||||
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | perilipin 2 | VGNC:4823 | 465012 | |||||
Mouse | MGI:87920 | 11520 | ||||||
Rat | RGD:728889 | 298199 | ||||||
Dog | perilipin 2 | VGNC:44691 | 100856329 | |||||
Horse | perilipin 2 | VGNC:21578 | 100052253 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | perilipin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | perilipin 2 | |||||
Horse | perilipin 2 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (13)
Reactome (8)
KEGG (1)
PathwayCommons (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Autophagy | ||||
Reactome | Chaperone Mediated Autophagy | ||||
Reactome | Lipophagy | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Autophagy | ||||
Chaperone Mediated Autophagy | ||||
Lipophagy | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Gene Ontology Terms (11)
Components (6)
Processes (5)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (143)
1 – 10 of 143
PPARA
Family: NR
Novelty: 0.00017403
Score: 0.951
Data Source: STRINGDB
FABP1
Novelty: 0.00192691
Score: 0.943
Data Source: STRINGDB
RXRA
Family: NR
Novelty: 0.00244343
Score: 0.923
Data Source: STRINGDB
ABHD5
Family: Enzyme
Novelty: 0.00806614
Score: 0.909
Data Source: STRINGDB
NCOA1
Family: Epigenetic
Novelty: 0.00344663
Score: 0.906
Data Source: STRINGDB
NCOA2
Novelty: 0.00510052
Score: 0.904
Data Source: STRINGDB
HELZ2
Family: Enzyme
Novelty: 0.1810765
Score: 0.902
Data Source: STRINGDB
MED1
Family: Enzyme
Novelty: 0.00852082
Score: 0.902
Data Source: STRINGDB
CREBBP
Family: Epigenetic
Novelty: 0.00111166
Score: 0.902
Data Source: STRINGDB
CHD9
Family: Epigenetic
Novelty: 0.06234268
Score: 0.901
Data Source: STRINGDB
Publication Statistics
PubMed Score 551.61
PubMed score by year
PubTator Score 297.89
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
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MGI Phenotype
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