Tchem LGMN Legumain

Protein Summary

Description

Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q99538
• O00123
• Q86TV2
• Q86TV3
• Q9BTY1

Gene Name

• LGMN

Ensembl ID

• ENST00000334869
• ENSP00000334052
• ENSG00000100600
• ENST00000393218
• ENSP00000376911
• ENST00000555699
• ENSP00000451861
• ENST00000557434
• ENSP00000452572

Symbol

• PRSC1
• AEP
• LGMN1
• PRSC1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
transcription factor perturbation	0.99
interacting protein	0.96
gene perturbation	0.88
histone modification site profile	0.82

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Legumain

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Legumain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 432.46   (req: < 5)

Gene RIFs: 61   (req: <= 3)

Antibodies: 291   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 432.46   (req: >= 5)

Gene RIFs: 61   (req: > 3)

Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 98

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0