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Tchem
LGMN
Legumain

Protein Summary
Description
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334869
  • ENSP00000334052
  • ENSG00000100600
  • ENST00000393218
  • ENSP00000376911
  • ENST00000555699
  • ENSP00000451861
  • ENST00000557434
  • ENSP00000452572

Symbol
  • PRSC1
  • AEP
  • LGMN1
  • PRSC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.99
interacting protein
0.96
gene perturbation
0.88
histone modification site profile
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 359.4   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 291   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 359.4   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 68
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
1
1
26.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
26.3
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
legumain
VGNC:3397
453118
Macaque
legumain
703734
Mouse
MGI:1330838
19141
Rat
RGD:619832
63865
Dog
legumain
VGNC:42654
480232
Species
Name
OMA
EggNOG
Inparanoid
Chimp
legumain
Macaque
legumain
Mouse
Rat
Dog
legumain
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99538-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Innate Immune System
Reactome
MHC class II antigen presentation
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Innate Immune System
MHC class II antigen presentation
Metabolism
Gene Ontology Terms (36)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
MGI
Protein-Protein Interactions (85)
1 – 10 of 85
PDIA5
Tbio
Family: Enzyme
Novelty: 0.06234465
p_int: 0.92974083
p_ni: 0.07025917
Score: 0.313
Data Source: BioPlex,STRINGDB
DEFA1
Tbio
Novelty: 0.01027492
p_int: 0.887730319
p_ni: 0.112269681
Data Source: BioPlex
ATG7
Tbio
Novelty: 0.00120728
p_int: 0.811678084
p_ni: 0.188321908
p_wrong: 8e-9
Score: 0.259
Data Source: BioPlex,STRINGDB
CST6
Tbio
Novelty: 0.02811473
Score: 0.965
Data Source: STRINGDB
CD74
Tchem
Novelty: 0.00281228
Score: 0.929
Data Source: Reactome,STRINGDB
TLR7
Tclin
Novelty: 0.00067036
Score: 0.919
Data Source: STRINGDB
HLA-DQA1
Tbio
Novelty: 0.00077488
Score: 0.917
Data Source: Reactome,STRINGDB
CUBN
Tbio
Novelty: 0.00441944
Score: 0.914
Data Source: STRINGDB
HLA-DRB1
Tchem
Novelty: 0.00240724
Score: 0.905
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.905
Data Source: STRINGDB
Publication Statistics
PubMed Score  359.40

PubMed score by year
PubTator Score  85.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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