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Tbio
VAT1
Synaptic vesicle membrane protein VAT-1 homolog

Protein Summary
Description
Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2). Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355653
  • ENSP00000347872
  • ENSG00000108828
  • ENST00000420567
  • ENSP00000408553
  • ENST00000587173
  • ENSP00000465946

Symbol
  • VATI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
interacting protein
0.87
protein domain
0.85
small molecule perturbation
0.71
transcription factor binding site profile
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.25   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.25   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
83.9
myeloid white cell count
1
1
1
73.5
leukocyte count
1
1
1
27
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
83.9
myeloid white cell count
1
73.5
leukocyte count
1
27
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vesicle amine transport 1
VGNC:14217
454708
Macaque
vesicle amine transport 1
100424563
Mouse
MGI:1349450
26949
Rat
RGD:1308943
287721
Dog
vesicle amine transport 1 [Source:HGNC Symbol;Acc:HGNC:16919]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vesicle amine transport 1
Macaque
vesicle amine transport 1
Mouse
Rat
Dog
vesicle amine transport 1 [Source:HGNC Symbol;Acc:HGNC:16919]
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (102)
1 – 10 of 102
PSMD1
Tbio
Family: Enzyme
Novelty: 0.02168311
Score: 0.923
Data Source: STRINGDB
SDCBP
Tbio
Novelty: 0.00242211
Score: 0.92
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.915
Data Source: STRINGDB
FUCA1
Tchem
Family: Enzyme
Novelty: 0.00961721
Score: 0.913
Data Source: STRINGDB
CYB5R3
Tbio
Family: Enzyme
Novelty: 0.00774258
Score: 0.912
Data Source: STRINGDB
PRDX6
Tbio
Novelty: 0.00180564
Score: 0.911
Data Source: STRINGDB
ACLY
Tclin
Family: Enzyme
Novelty: 0.00114812
Score: 0.911
Data Source: STRINGDB
ANXA2
Tbio
Novelty: 0.00103362
Score: 0.911
Data Source: STRINGDB
CTSA
Tchem
Family: Enzyme
Novelty: 0.00170931
Score: 0.911
Data Source: STRINGDB
CCT2
Tbio
Novelty: 0.01967139
Score: 0.909
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.25

PubMed score by year
PubTator Score  38.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer