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Tchem
GPER1
G-protein coupled estrogen receptor 1

Protein Summary
Description
G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitoch ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297469
  • ENSP00000297469
  • ENSG00000164850
  • ENST00000397088
  • ENSP00000380277
  • ENST00000397092
  • ENSP00000380281
  • ENST00000401670
  • ENSP00000385151

Symbol
  • CEPR
  • CMKRL2
  • DRY12
  • GPER
  • GPR30
  • mER
  • CEPR
  • GPER
  • DRY12
  • FEG-1
  • GPR30
  • LERGU
  • LyGPR
  • CMKRL2
  • LERGU2
  • GPCR-Br
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
gene perturbation
0.99
cellular component
0.9
biological term
0.81
molecular function
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1013   (req: < 5)
Gene RIFs: 182   (req: <= 3)
Antibodies: 394   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1013   (req: >= 5)
Gene RIFs: 182   (req: > 3)
Antibodies: 394   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 59
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (291)
S1PR1
Tclin
Family:  GPCR
Novelty:  0.00162513
Score:  0.945
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.941
Data Source:  STRINGDB
NPY
Tbio
Novelty:  0.00012637
Score:  0.93
Data Source:  STRINGDB
GRM2
Tchem
Family:  GPCR
Novelty:  0.00132156
Score:  0.928
Data Source:  STRINGDB
GRM8
Tchem
Family:  GPCR
Novelty:  0.00827879
Score:  0.927
Data Source:  STRINGDB
CASR
Tclin
Family:  GPCR
Novelty:  0.00061316
Score:  0.926
Data Source:  STRINGDB
HTR1A
Tclin
Family:  GPCR
Novelty:  0.00015658
Score:  0.923
Data Source:  STRINGDB
GABBR1
Tclin
Family:  GPCR
Novelty:  0.00086493
Score:  0.921
Data Source:  STRINGDB
GRM3
Tchem
Family:  GPCR
Novelty:  0.00340947
Score:  0.921
Data Source:  STRINGDB
AGT
Tbio
Novelty:  0.00049613
Score:  0.919
Data Source:  STRINGDB
Pathways (12)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (87)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
5
4
5
88.8
high density lipoprotein cholesterol measurement
1
2
2
88.8
total cholesterol measurement
3
3
3
86.8
reticulocyte measurement
2
3
3
83.5
apolipoprotein A 1 measurement
2
2
2
82.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
5
88.8
high density lipoprotein cholesterol measurement
2
88.8
total cholesterol measurement
3
86.8
reticulocyte measurement
3
83.5
apolipoprotein A 1 measurement
2
82.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
G protein-coupled estrogen receptor 1
696625
Mouse
MGI:1924104
76854
Rat
RGD:619845
171104
Dog
G protein-coupled estrogen receptor 1
VGNC:41379
480808
Horse
G protein-coupled estrogen receptor 1
VGNC:18491
102148430
Species
Name
OMA
EggNOG
Inparanoid
Macaque
G protein-coupled estrogen receptor 1
Mouse
Rat
Dog
G protein-coupled estrogen receptor 1
Horse
G protein-coupled estrogen receptor 1
Publication Statistics
PubMed Score 1013.00
PubMed score by year
PubTator Score 433.82
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title