Protein Classes
Protein Summary
Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. This gene encodes a member of the VPS10-rel ...more
- ENST00000256637
- ENSP00000256637
- ENSG00000134243
- ENST00000538502
- ENSP00000438597
- NT3
- Gp95
- NTR3
- LDLCQ6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.99 | ||
transcription factor perturbation | 0.96 | ||
cellular component | 0.8 | ||
kinase perturbation | 0.76 | ||
disease | 0.71 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 336.31 (req: < 5)
Gene RIFs: 95 (req: <= 3)
Antibodies: 233 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 336.31 (req: >= 5)
Gene RIFs: 95 (req: > 3)
Antibodies: 233 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 16
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (16)
1 – 10 of 16
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glomerular filtration rate | 2 | 2 | 1 | 7.9 | 70.1 | ||||
intelligence | 1 | 1 | 0 | 6.1 | 31.6 | ||||
creatinine measurement | 1 | 1 | 1 | 25.1 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glomerular filtration rate | 1 | 7.9 | 70.1 | ||||
intelligence | 0 | 6.1 | 31.6 | ||||
creatinine measurement | 1 | 25.1 | |||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | sortilin 1 | 698310 | ||||||
Mouse | MGI:1338015 | 20661 | ||||||
Rat | RGD:619999 | 83576 | ||||||
Dog | sortilin 1 | VGNC:46664 | 479915 | |||||
Horse | sortilin 1 | VGNC:23453 | 100061385 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | sortilin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | sortilin 1 | |||||
Horse | sortilin 1 | |||||
Protein Structure (9 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 9
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (264)
Reactome (4)
KEGG (3)
PathwayCommons (1)
WikiPathways (256)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Golgi Associated Vesicle Biogenesis | ||||
Reactome | Membrane Trafficking | ||||
Reactome | Vesicle-mediated transport | ||||
Reactome | trans-Golgi Network Vesicle Budding | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Golgi Associated Vesicle Biogenesis | ||||
Membrane Trafficking | ||||
Vesicle-mediated transport | ||||
trans-Golgi Network Vesicle Budding | ||||
Gene Ontology Terms (42)
Functions (4)
Components (19)
Processes (19)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Protein-Protein Interactions (186)
1 – 10 of 186
NGFR
Novelty: 0.00072052
Score: 0.989
Data Source: STRINGDB
NGF
Novelty: 0.00008139
Score: 0.981
Data Source: STRINGDB
BDNF
Novelty: 0.00006891
Score: 0.979
Data Source: STRINGDB
IGF2R
Novelty: 0.00138374
Score: 0.968
Data Source: STRINGDB
SNX2
Novelty: 0.03880384
Score: 0.956
Data Source: STRINGDB
APOB
Novelty: 0.00008247
Score: 0.951
Data Source: STRINGDB
MAGEH1
Novelty: 0.00457617
Score: 0.941
Data Source: STRINGDB
MAGED1
Novelty: 0.02143963
Score: 0.939
Data Source: STRINGDB
RAB5C
Family: Enzyme
Novelty: 0.02952779
Score: 0.938
Data Source: STRINGDB
AP1G1
Novelty: 0.03754132
Score: 0.937
Data Source: STRINGDB
Publication Statistics
PubMed Score 336.31
PubMed score by year
PubTator Score 239.96
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword