Protein Summary
Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. This gene encodes a member of the VPS10-rel ...more
- ENST00000256637
- ENSP00000256637
- ENSG00000134243
- ENST00000538502
- ENSP00000438597
- NT3
- Gp95
- NTR3
- LDLCQ6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.99 | ||
transcription factor perturbation | 0.96 | ||
cellular component | 0.8 | ||
kinase perturbation | 0.76 | ||
disease | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 349.6 (req: < 5)
Gene RIFs: 95 (req: <= 3)
Antibodies: 233 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 349.6 (req: >= 5)
Gene RIFs: 95 (req: > 3)
Antibodies: 233 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 17
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (17)
Protein-Protein Interactions (186)
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (264)
Reactome (4)
KEGG (3)
PathwayCommons (1)
WikiPathways (256)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Golgi Associated Vesicle Biogenesis | ||||
Reactome | Membrane Trafficking | ||||
Reactome | Vesicle-mediated transport | ||||
Reactome | trans-Golgi Network Vesicle Budding | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Golgi Associated Vesicle Biogenesis | ||||
Membrane Trafficking | ||||
Vesicle-mediated transport | ||||
trans-Golgi Network Vesicle Budding | ||||
Viral Interactions (0)
Gene Ontology Terms (42)
Functions (4)
Components (19)
Processes (19)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Disease Associations (null)
GWAS Traits (46)
Items per page:
1 – 5 of 46
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 27 | 31 | 68 | 5.5 | 99.9 | ||||
apolipoprotein B measurement | 3 | 25 | 27 | 99.9 | |||||
total cholesterol measurement | 16 | 23 | 51 | 6.2 | 99.9 | ||||
apolipoprotein A 1 measurement | 3 | 5 | 5 | 98.3 | |||||
13 | 6 | 4 | 1.1 | 98.2 | |||||
Items per page:
1 – 5 of 46
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 68 | 5.5 | 99.9 | ||||
apolipoprotein B measurement | 27 | 99.9 | |||||
total cholesterol measurement | 51 | 6.2 | 99.9 | ||||
apolipoprotein A 1 measurement | 5 | 98.3 | |||||
4 | 1.1 | 98.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | sortilin 1 | 698310 | ||||||
Mouse | MGI:1338015 | 20661 | ||||||
Rat | RGD:619999 | 83576 | ||||||
Dog | sortilin 1 | VGNC:46664 | 479915 | |||||
Horse | sortilin 1 | VGNC:23453 | 100061385 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | sortilin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | sortilin 1 | |||||
Horse | sortilin 1 | |||||
Publication Statistics
PubMed Score 349.60
PubMed score by year
PubTator Score 239.96
PubTator score by year
Related Publications
Text Mined References (154)
GeneRif Annotations (95)
Items per page:
0 of 0
PMID | Year | Title |
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