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Tchem
SORT1
Sortilin

Protein Summary
Description
Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. This gene encodes a member of the VPS10-rel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256637
  • ENSP00000256637
  • ENSG00000134243
  • ENST00000538502
  • ENSP00000438597

Symbol
  • NT3
  • Gp95
  • NTR3
  • LDLCQ6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor perturbation
0.96
cellular component
0.8
kinase perturbation
0.76
disease
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.31   (req: < 5)
Gene RIFs: 95   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.31   (req: >= 5)
Gene RIFs: 95   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
2
1
7.9
70.1
intelligence
1
1
0
6.1
31.6
creatinine measurement
1
1
1
25.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
7.9
70.1
intelligence
0
6.1
31.6
creatinine measurement
1
25.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
sortilin 1
698310
Mouse
MGI:1338015
20661
Rat
RGD:619999
83576
Dog
sortilin 1
VGNC:46664
479915
Horse
sortilin 1
VGNC:23453
100061385
Species
Name
OMA
EggNOG
Inparanoid
Macaque
sortilin 1
Mouse
Rat
Dog
sortilin 1
Horse
sortilin 1
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99523-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (264)
Golgi Associated Vesicle Biogenesis (R-HSA-432722)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Reactome
trans-Golgi Network Vesicle Budding
Name
Explore in Pharos
Explore in Source
Golgi Associated Vesicle Biogenesis
Membrane Trafficking
Vesicle-mediated transport
trans-Golgi Network Vesicle Budding
Protein-Protein Interactions (186)
1 – 10 of 186
NGFR
Tclin
Novelty: 0.00072052
Score: 0.989
Data Source: STRINGDB
NGF
Tchem
Novelty: 0.00008139
Score: 0.981
Data Source: STRINGDB
BDNF
Tbio
Novelty: 0.00006891
Score: 0.979
Data Source: STRINGDB
IGF2R
Tchem
Novelty: 0.00138374
Score: 0.968
Data Source: STRINGDB
SNX2
Tbio
Novelty: 0.03880384
Score: 0.956
Data Source: STRINGDB
APOB
Tchem
Novelty: 0.00008247
Score: 0.951
Data Source: STRINGDB
MAGEH1
Tbio
Novelty: 0.00457617
Score: 0.941
Data Source: STRINGDB
MAGED1
Tbio
Novelty: 0.02143963
Score: 0.939
Data Source: STRINGDB
RAB5C
Tbio
Family: Enzyme
Novelty: 0.02952779
Score: 0.938
Data Source: STRINGDB
AP1G1
Tbio
Novelty: 0.03754132
Score: 0.937
Data Source: STRINGDB
Publication Statistics
PubMed Score  336.31

PubMed score by year
PubTator Score  239.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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