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Tchem
NEU1
Sialidase-1

Protein Summary
Description
Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229725
  • ENSP00000229725
  • ENSG00000184494
  • ENST00000375631
  • ENSP00000364782
  • ENSG00000204386
  • ENST00000411774
  • ENSP00000399309
  • ENSG00000234846
  • ENST00000422978
  • ENSP00000408957
  • ENSG00000227129
  • ENST00000423382
  • ENSP00000401067
  • ENSG00000228691
  • ENST00000434496
  • ENSP00000409489
  • ENSG00000234343
  • ENST00000437432
  • ENSP00000403720
  • ENSG00000223957
  • ENST00000439648
  • ENSP00000408207
  • ENSG00000227315

Symbol
  • NANH
  • NEU
  • NANH
  • SIAL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
cellular component
0.82
transcription factor binding site profile
0.76
disease perturbation
0.74
transcription factor perturbation
0.74


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.17   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 341   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.17   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0