Protein Summary
Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity. [provided by RefSeq, Jul 2008]
- ENST00000229725
- ENSP00000229725
- ENSG00000184494
- ENST00000375631
- ENSP00000364782
- ENSG00000204386
- ENST00000411774
- ENSP00000399309
- ENSG00000234846
- ENST00000422978
- ENSP00000408957
- ENSG00000227129
- ENST00000423382
- ENSP00000401067
- ENSG00000228691
- ENST00000434496
- ENSP00000409489
- ENSG00000234343
- ENST00000437432
- ENSP00000403720
- ENSG00000223957
- ENST00000439648
- ENSP00000408207
- ENSG00000227315
- NANH
- NEU
- NANH
- SIAL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.91 | ||
cellular component | 0.82 | ||
transcription factor binding site profile | 0.76 | ||
disease perturbation | 0.74 | ||
transcription factor perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 243.54 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 341 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 243.54 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 341 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 11
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (11)
Protein-Protein Interactions (119)
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
Pathways (22)
Reactome (17)
KEGG (4)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Reactome | Defective NEU1 causes sialidosis | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with glycosylation precursor biosynthesis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Defective NEU1 causes sialidosis | ||||
Disease | ||||
Diseases associated with glycosylation precursor biosynthesis | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (5)
Components (10)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations ()
GWAS Traits (438)
Items per page:
1 – 5 of 438
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
9 | 8 | 0 | 1.9 | 99.2 | ||||||
9 | 8 | 0 | 1.9 | 99.2 | ||||||
9 | 8 | 0 | 1.9 | 99.2 | ||||||
9 | 8 | 0 | 1.9 | 99.2 | ||||||
9 | 8 | 0 | 1.9 | 99.2 | ||||||
Items per page:
1 – 5 of 438
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.9 | 99.2 | |||||
0 | 1.9 | 99.2 | |||||
0 | 1.9 | 99.2 | |||||
0 | 1.9 | 99.2 | |||||
0 | 1.9 | 99.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | neuraminidase 1 | 716740 | ||||||
Mouse | MGI:97305 | 18010 | ||||||
Rat | RGD:3163 | 24591 | ||||||
Dog | neuraminidase 1 | 481717 | ||||||
Horse | neuraminidase 1 | VGNC:49500 | 100059083 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | neuraminidase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | neuraminidase 1 | |||||
Horse | neuraminidase 1 | |||||
Publication Statistics
PubMed Score 243.54
PubMed score by year
PubTator Score 6521.87
PubTator score by year
Related Publications
Text Mined References (86)
GeneRif Annotations (55)
Items per page:
0 of 0
PMID | Year | Title |
|---|