You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
EYA3
Eyes absent homolog 3

Protein Summary
Description
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373863
  • ENSP00000362970
  • ENSG00000158161
  • ENST00000373871
  • ENSP00000362978
  • ENST00000436342
  • ENSP00000405587
  • ENST00000540618
  • ENSP00000442558
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.82
biological process
0.77
histone modification site profile
0.76
kinase perturbation
0.76
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.53   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.53   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (63)
1 – 10 of 63
SIX2
Tbio
Family:  TF
Novelty:  0.01046481
p_int:  0.999999924
p_ni:  7.5e-8
Score:  0.898
Data Source:  BioPlex,STRINGDB
TCEAL1
Tbio
Novelty:  0.02210924
p_int:  0.99999567
p_ni:  0.000004304
p_wrong:  2.7e-8
Score:  0.242
Data Source:  BioPlex,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
Score:  0.951
Data Source:  Reactome,STRINGDB
MDC1
Tbio
Novelty:  0.00533097
Score:  0.938
Data Source:  STRINGDB
ATM
Tchem
Family:  Kinase
Novelty:  0.00019169
Score:  0.922
Data Source:  Reactome,STRINGDB
NBN
Tbio
Novelty:  0.00759456
Score:  0.907
Data Source:  Reactome,STRINGDB
EYA2
Tbio
Novelty:  0.01972903
Score:  0.907
Data Source:  STRINGDB
EYA4
Tbio
Novelty:  0.01905381
Score:  0.904
Data Source:  STRINGDB
EYA1
Tbio
Novelty:  0.00585286
Score:  0.904
Data Source:  STRINGDB
SIX1
Tbio
Family:  TF
Novelty:  0.00415613
Score:  0.904
Data Source:  STRINGDB
Pathways (4)
DNA Double Strand Break Response (R-HSA-5693606)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double Strand Break Response
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Name
Explore in Pharos
Explore in Source
DNA Double Strand Break Response
DNA Double-Strand Break Repair
DNA Repair
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
87.8
1
1
0
1.6
76.5
monocyte count
1
1
1
68.8
red blood cell distribution width
2
1
2
62.1
high density lipoprotein cholesterol measurement
2
2
2
57.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
87.8
0
1.6
76.5
monocyte count
1
68.8
red blood cell distribution width
2
62.1
high density lipoprotein cholesterol measurement
2
57.1
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
EYA transcriptional coactivator and phosphatase 3
716724
Mouse
MGI:109339
14050
Rat
RGD:1309932
313027
Dog
EYA transcriptional coactivator and phosphatase 3
VGNC:40538
610061
Horse
EYA transcriptional coactivator and phosphatase 3
VGNC:17747
100070791
Species
Name
OMA
EggNOG
Inparanoid
Macaque
EYA transcriptional coactivator and phosphatase 3
Mouse
Rat
Dog
EYA transcriptional coactivator and phosphatase 3
Horse
EYA transcriptional coactivator and phosphatase 3
Publication Statistics
PubMed Score 21.53
PubMed score by year
PubTator Score 11.61
PubTator score by year