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Tbio
GAS2L1
GAS2-like protein 1

Protein Summary
Description
Seems to be involved in the cross-linking of microtubules and microfilaments. This gene encodes a member of the growth arrest-specific 2 protein family. This protein binds components of the cytoskeleton and may be involved in mediating interactions between microtubules and microfilaments. This protein localizes to the proximal end of mature centrioles and links centrosomes to both microtubules and actin. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, May 2018]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000406549
  • ENSP00000383995
  • ENSG00000185340
  • ENST00000610653
  • ENSP00000484130

Symbol
  • GAR22
  • GAR22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
transcription factor binding site profile
0.76
histone modification site profile
0.64
PubMedID
0.63
disease perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.63   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.63   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (38)
1 – 10 of 38
MAPRE3
Tbio
Novelty:  0.00454315
p_int:  0.999999999
p_ni:  1e-9
Score:  0.896
Data Source:  BioPlex,STRINGDB
EPN1
Tbio
Novelty:  0.01788784
p_int:  0.999990323
p_ni:  0.000009677
Score:  0.232
Data Source:  BioPlex,STRINGDB
PLCG1
Tchem
Family:  Enzyme
Novelty:  0.00110273
p_int:  0.999881253
p_ni:  0.000118747
Data Source:  BioPlex
MAPRE1
Tbio
Novelty:  0.01267772
p_int:  0.998933349
p_ni:  0.001066651
Score:  0.71
Data Source:  BioPlex,STRINGDB
SH3KBP1
Tbio
Family:  Enzyme
Novelty:  0.01454593
p_int:  0.997688868
p_ni:  0.002311132
Score:  0.198
Data Source:  BioPlex,STRINGDB
WDR45B
Tbio
Novelty:  0.22407227
p_int:  0.997290261
p_ni:  0.002709739
Data Source:  BioPlex
GNB1L
Tbio
Novelty:  0.03388865
p_int:  0.997106137
p_ni:  0.002893848
p_wrong:  1.5e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
CDKN2C
Tbio
Family:  Enzyme
Novelty:  0.00806886
p_int:  0.996125206
p_ni:  0.001663084
p_wrong:  0.00221171
Score:  0.257
Data Source:  BioPlex,STRINGDB
DIS3
Tbio
Family:  Enzyme
Novelty:  0.00961238
p_int:  0.990230641
p_ni:  0.009769359
Score:  0.248
Data Source:  BioPlex,STRINGDB
KLHL42
Tdark
Novelty:  0.25822395
p_int:  0.978329905
p_ni:  0.021670084
p_wrong:  1.1e-8
Score:  0.15
Data Source:  BioPlex,STRINGDB
Pathways (12)
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Ectoderm Differentiation
WikiPathways
Ectoderm Differentiation
WikiPathways
Ectoderm Differentiation
WikiPathways
Ectoderm Differentiation
WikiPathways
Heart Development
Name
Explore in Pharos
Explore in Source
Ectoderm Differentiation
Ectoderm Differentiation
Ectoderm Differentiation
Ectoderm Differentiation
Heart Development
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
6
11
93.4
reticulocyte measurement
3
3
5
91
heel bone mineral density
3
3
5
89.5
monocyte count
2
2
2
89.4
mean platelet volume
3
2
3
86.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
11
93.4
reticulocyte measurement
5
91
heel bone mineral density
5
89.5
monocyte count
2
89.4
mean platelet volume
3
86.4
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
growth arrest specific 2 like 1
714530
Mouse
MGI:1926176
78926
Dog
growth arrest specific 2 like 1
VGNC:41116
486342
Horse
growth arrest specific 2 like 1
VGNC:18251
100064354
Cow
growth arrest specific 2 like 1
VGNC:29258
518935
Species
Name
OMA
EggNOG
Inparanoid
Macaque
growth arrest specific 2 like 1
Mouse
Dog
growth arrest specific 2 like 1
Horse
growth arrest specific 2 like 1
Cow
growth arrest specific 2 like 1
Publication Statistics
PubMed Score 7.63
PubMed score by year
PubTator Score 3.05
PubTator score by year