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Tclin
S1PR3
Sphingosine 1-phosphate receptor 3

Protein Summary
Description
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358157
  • ENSP00000350878
  • ENSG00000213694
  • ENST00000375846
  • ENSP00000365006

Symbol
  • EDG3
  • EDG3
  • LPB3
  • S1P3
  • EDG-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
gene perturbation
0.77
small molecule perturbation
0.68
cell type or tissue
0.66
disease
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.89   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 511   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.89   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 511   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 263
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (263)
sphingosine 1-phosphate
Rendered image for sphingosine 1-phosphate
CHEMBL3769933
Rendered image for CHEMBL3769933
fingolimod-phosphate
Rendered image for fingolimod-phosphate
Fingolimod phosphate
Rendered image for Fingolimod phosphate
ASP4058
Rendered image for ASP4058
CHEMBL194419
Rendered image for CHEMBL194419
CHEMBL1091103
Rendered image for CHEMBL1091103
FTY720-P(R)
Rendered image for FTY720-P(R)
CHEMBL184879
Rendered image for CHEMBL184879
Protein-Protein Interactions (256)
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.952
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.945
Data Source:  STRINGDB
GNA15
Tbio
Novelty:  0.00159196
Score:  0.944
Data Source:  STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.944
Data Source:  STRINGDB
GNA13
Tbio
Novelty:  0.04149138
Score:  0.939
Data Source:  STRINGDB
CXCR4
Tclin
Family:  GPCR
Novelty:  0.0002811
Score:  0.938
Data Source:  STRINGDB
CXCL12
Tchem
Novelty:  0.00026817
Score:  0.937
Data Source:  STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
Score:  0.936
Data Source:  STRINGDB
GNA11
Tchem
Novelty:  0.00128664
Score:  0.936
Data Source:  STRINGDB
CXCL13
Tbio
Novelty:  0.00118688
Score:  0.933
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
ESR-mediated signaling
Reactome
Extra-nuclear estrogen signaling
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
ESR-mediated signaling
Extra-nuclear estrogen signaling
G alpha (i) signalling events
GPCR downstream signalling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
3
3
93
monocyte count
3
4
4
92
HbA1c measurement
1
1
1
35
myeloid white cell count
1
1
1
27.9
leukocyte count
2
2
2
21.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
3
93
monocyte count
4
92
HbA1c measurement
1
35
myeloid white cell count
1
27.9
leukocyte count
2
21.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sphingosine-1-phosphate receptor 3
VGNC:13958
464580
Mouse
MGI:1339365
13610
Rat
RGD:1583843
306792
Dog
sphingosine-1-phosphate receptor 3
VGNC:45837
484199
Horse
sphingosine-1-phosphate receptor 3
VGNC:22662
100061893
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sphingosine-1-phosphate receptor 3
Mouse
Rat
Dog
sphingosine-1-phosphate receptor 3
Horse
sphingosine-1-phosphate receptor 3
Publication Statistics
PubMed Score 245.89
PubMed score by year
PubTator Score 133.40
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title