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Tclin
S1PR3
Sphingosine 1-phosphate receptor 3

Protein Summary
Description
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358157
  • ENSP00000350878
  • ENSG00000213694
  • ENST00000375846
  • ENSP00000365006

Symbol
  • EDG3
  • EDG3
  • LPB3
  • S1P3
  • EDG-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
gene perturbation
0.77
small molecule perturbation
0.68
cell type or tissue
0.66
disease
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 239.27   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 511   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 239.27   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 511   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 226
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
1
1
17.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
17.9
Pathways (16)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
ESR-mediated signaling
Reactome
Extra-nuclear estrogen signaling
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
ESR-mediated signaling
Extra-nuclear estrogen signaling
G alpha (i) signalling events
GPCR downstream signalling
Protein-Protein Interactions (256)
1 – 10 of 256
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.952
Data Source: STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.945
Data Source: STRINGDB
GNA15
Tbio
Novelty: 0.00159196
Score: 0.944
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.944
Data Source: STRINGDB
GNA13
Tbio
Novelty: 0.04149138
Score: 0.939
Data Source: STRINGDB
CXCR4
Tclin
Family: GPCR
Novelty: 0.0002811
Score: 0.938
Data Source: STRINGDB
CXCL12
Tbio
Novelty: 0.00026817
Score: 0.937
Data Source: STRINGDB
GNAQ
Tbio
Novelty: 0.0008997
Score: 0.936
Data Source: STRINGDB
GNA11
Tbio
Novelty: 0.00128664
Score: 0.936
Data Source: STRINGDB
CXCL13
Tbio
Novelty: 0.00118688
Score: 0.933
Data Source: STRINGDB
Publication Statistics
PubMed Score  239.27

PubMed score by year
PubTator Score  133.4

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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