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Tbio
PARK7
Protein/nucleic acid deglycase DJ-1

Protein Summary
Description
Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals (PubMed:25416785, PubMed:28596309). Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (PubMed:25416785, PubMed:28013050, PubMed:26995087). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338639
  • ENSP00000340278
  • ENSG00000116288
  • ENST00000377488
  • ENSP00000366708
  • ENST00000377491
  • ENSP00000366711
  • ENST00000493373
  • ENSP00000465404
  • ENST00000493678
  • ENSP00000418770

Symbol
  • DJ1
  • DJ-1
  • GATD2
  • HEL-S-67p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease perturbation
1
kinase perturbation
1
molecular function
1
biological term
0.99


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1141.87   (req: < 5)
Gene RIFs: 312   (req: <= 3)
Antibodies: 808   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1141.87   (req: >= 5)
Gene RIFs: 312   (req: > 3)
Antibodies: 808   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 118
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
2
0
1.2
76.2
2
2
0
1.1
71.8
1
1
0
1.1
64.9
C-reactive protein measurement
1
1
1
45.1
BMI-adjusted waist circumference
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.2
76.2
0
1.1
71.8
0
1.1
64.9
C-reactive protein measurement
1
45.1
BMI-adjusted waist circumference
1
33.1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Parkinsonism associated deglycase
VGNC:12952
746063
Macaque
Parkinsonism associated deglycase
708377
Mouse
MGI:2135637
57320
Rat
RGD:621808
117287
Dog
Parkinsonism associated deglycase
VGNC:44266
479595
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Parkinsonism associated deglycase
Macaque
Parkinsonism associated deglycase
Mouse
Rat
Dog
Parkinsonism associated deglycase
Protein Structure (61 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99497-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 61
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
SUMO E3 ligases SUMOylate target proteins
Reactome
SUMOylation
Reactome
SUMOylation of transcription cofactors
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
SUMO E3 ligases SUMOylate target proteins
SUMOylation
SUMOylation of transcription cofactors
Gene Ontology Terms (136)
Items per page:
10
1 – 10 of 27
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (344)
1 – 10 of 344
SNCA
Tchem
Novelty:  0.00012042
Score:  0.99
Data Source:  STRINGDB
PINK1
Tbio
Family:  Kinase
Novelty:  0.00100973
Score:  0.988
Data Source:  STRINGDB
PRKN
Tbio
Family:  Enzyme
Novelty:  0.00079898
Score:  0.979
Data Source:  STRINGDB
SUMO1
Tbio
Novelty:  0.00137629
Score:  0.962
Data Source:  Reactome,STRINGDB
LRRK2
Tchem
Family:  Kinase
Novelty:  0.00068078
Score:  0.958
Data Source:  STRINGDB
UBE2I
Tbio
Novelty:  0.00267883
Score:  0.945
Data Source:  Reactome,STRINGDB
PRDX2
Tbio
Novelty:  0.00189751
Score:  0.943
Data Source:  STRINGDB
SOD1
Tchem
Family:  Enzyme
Novelty:  0.00039653
Score:  0.936
Data Source:  STRINGDB
PTEN
Tchem
Family:  Enzyme
Novelty:  0.00013818
Score:  0.923
Data Source:  STRINGDB
PRDX5
Tbio
Novelty:  0.00369421
Score:  0.921
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1141.87

PubMed score by year
PubTator Score  593.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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