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Tbio
RNF2
E3 ubiquitin-protein ligase RING2

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15386022, PubMed:16359901, PubMed:25519132, PubMed:21772249, PubMed:25355358, PubMed:26151332). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation (By similarity). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16359901, PubMed:26151332). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:26151332). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:21772249). Acts as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367509
  • ENSP00000356479
  • ENSG00000121481
  • ENST00000367510
  • ENSP00000356480

Symbol
  • BAP1
  • DING
  • HIPI3
  • RING1B
  • BAP1
  • DING
  • BAP-1
  • HIPI3
  • RING2
  • RING1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor perturbation
0.94
virus perturbation
0.9
microRNA
0.8
biological process
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.04   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 405   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.04   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 405   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 2
VGNC:1497
457581
Mouse
MGI:1101759
19821
Rat
RGD:1305491
304850
Dog
ring finger protein 2
VGNC:45652
480042
Horse
ring finger protein 2
VGNC:22463
100056141
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 2
Mouse
Rat
Dog
ring finger protein 2
Horse
ring finger protein 2
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99496-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (43)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Gene expression (Transcription)
Generic Transcription Pathway
Protein-Protein Interactions (274)
1 – 10 of 274
PCGF2
Tbio
Novelty: 0.02148755
p_int: 0.999996823
p_ni: 0.000003177
Score: 0.988
Data Source: BioPlex,STRINGDB
PCGF6
Tbio
Novelty: 0.07032909
p_int: 0.999981911
p_ni: 0.000018089
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
RYBP
Tbio
Novelty: 0.01140945
p_int: 0.999977201
p_ni: 0.000022799
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
YAF2
Tbio
Novelty: 0.10772286
p_int: 0.999931334
p_ni: 0.000068666
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
PHC1
Tbio
Novelty: 0.01530622
p_int: 0.999849893
p_ni: 0.000150107
Score: 0.995
Data Source: BioPlex,STRINGDB
L3MBTL2
Tbio
Family: Epigenetic
Novelty: 0.11193867
p_int: 0.999130407
p_ni: 0.000869593
Score: 0.989
Data Source: BioPlex,Reactome,STRINGDB
PCGF5
Tdark
Novelty: 0.11370936
p_int: 0.998333244
p_ni: 0.001666756
Score: 0.996
Data Source: BioPlex,STRINGDB
CSNK2B
Tbio
Family: Kinase
Novelty: 0.00152367
p_int: 0.997306832
p_ni: 0.002693168
Score: 0.925
Data Source: BioPlex,STRINGDB
CSNK2A2
Tchem
Family: Kinase
Novelty: 0.00231447
p_int: 0.997067317
p_ni: 0.002932683
Score: 0.954
Data Source: BioPlex,STRINGDB
CBX7
Tchem
Family: Epigenetic
Novelty: 0.01612606
p_int: 0.996872127
p_ni: 0.003127873
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  137.04

PubMed score by year
PubTator Score  227.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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