You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RNF2
E3 ubiquitin-protein ligase RING2

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15386022, PubMed:16359901, PubMed:25519132, PubMed:21772249, PubMed:25355358, PubMed:26151332). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation (By similarity). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16359901, PubMed:26151332). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:26151332). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:21772249). Acts as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367509
  • ENSP00000356479
  • ENSG00000121481
  • ENST00000367510
  • ENSP00000356480

Symbol
  • BAP1
  • DING
  • HIPI3
  • RING1B
  • BAP1
  • DING
  • BAP-1
  • HIPI3
  • RING2
  • RING1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor perturbation
0.94
virus perturbation
0.9
microRNA
0.8
biological process
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.99   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 405   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.99   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 405   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (43)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Gene expression (Transcription)
Generic Transcription Pathway
Protein-Protein Interactions (274)
1 – 10 of 274
PCGF2
Tbio
Novelty: 0.02620321
p_int: 0.999996823
p_ni: 0.000003177
Score: 0.988
Data Source: BioPlex,STRINGDB
PCGF6
Tbio
Novelty: 0.132061
p_int: 0.999981911
p_ni: 0.000018089
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
RYBP
Tbio
Novelty: 0.01436012
p_int: 0.999977201
p_ni: 0.000022799
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
YAF2
Tbio
Novelty: 0.14775726
p_int: 0.999931334
p_ni: 0.000068666
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
PHC1
Tbio
Novelty: 0.02755105
p_int: 0.999849893
p_ni: 0.000150107
Score: 0.995
Data Source: BioPlex,STRINGDB
L3MBTL2
Tbio
Family: Epigenetic
Novelty: 0.13882316
p_int: 0.999130407
p_ni: 0.000869593
Score: 0.989
Data Source: BioPlex,Reactome,STRINGDB
PCGF5
Tdark
Novelty: 0.18178301
p_int: 0.998333244
p_ni: 0.001666756
Score: 0.996
Data Source: BioPlex,STRINGDB
CSNK2B
Tbio
Family: Kinase
Novelty: 0.00171173
p_int: 0.997306832
p_ni: 0.002693168
Score: 0.925
Data Source: BioPlex,STRINGDB
CSNK2A2
Tchem
Family: Kinase
Novelty: 0.00420757
p_int: 0.997067317
p_ni: 0.002932683
Score: 0.954
Data Source: BioPlex,STRINGDB
CBX7
Tchem
Family: Epigenetic
Novelty: 0.02468981
p_int: 0.996872127
p_ni: 0.003127873
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  126.99

PubMed score by year
PubTator Score  227.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: