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Tbio
AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

Protein Summary
Description
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Altern ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257897
  • ENSP00000257897
  • ENSG00000135439

Symbol
  • CENTG1
  • KIAA0167
  • PIKE
  • GGAP2
  • CENTG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
protein domain
0.92
kinase perturbation
0.84
cellular component
0.76
cell line
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.08   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 278   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.08   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
0
1.1
94
urate measurement
1
1
1
71.9
high density lipoprotein cholesterol measurement
1
1
1
59.9
mathematical ability
2
2
2
57.7
apolipoprotein A 1 measurement
1
1
1
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
94
urate measurement
1
71.9
high density lipoprotein cholesterol measurement
1
59.9
mathematical ability
2
57.7
apolipoprotein A 1 measurement
1
52.7
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
VGNC:12757
452023
Macaque
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
715504
Mouse
MGI:3580016
216439
Rat
RGD:628844
65218
Dog
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
481130
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Macaque
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Mouse
Rat
Dog
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99490-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (109)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Netrin-1 signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Netrin-1 signaling
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ARUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (67)
1 – 10 of 67
EPB41L1
Tbio
Novelty:  0.02937451
Score:  0.975
Data Source:  STRINGDB
UNC5B
Tbio
Novelty:  0.01474065
Score:  0.949
Data Source:  Reactome,STRINGDB
PIK3R1
Tchem
Family:  Kinase
Novelty:  0.00179772
Score:  0.94
Data Source:  STRINGDB
FYN
Tclin
Family:  Kinase
Novelty:  0.00072167
Score:  0.92
Data Source:  STRINGDB
NGF
Tchem
Novelty:  0.00008139
Score:  0.915
Data Source:  STRINGDB
PIK3CA
Tclin
Family:  Kinase
Novelty:  0.00044273
Score:  0.915
Data Source:  STRINGDB
NTN1
Tbio
Novelty:  0.00183678
Score:  0.906
Data Source:  STRINGDB
NTRK1
Tclin
Family:  Kinase
Novelty:  0.00033453
Score:  0.906
Data Source:  STRINGDB
GRM1
Tchem
Family:  GPCR
Novelty:  0.00099764
Score:  0.892
Data Source:  STRINGDB
LGMN
Tchem
Family:  Enzyme
Novelty:  0.00296582
Score:  0.804
Data Source:  STRINGDB
Publication Statistics
PubMed Score  31.08

PubMed score by year
PubTator Score  177.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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