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Tchem
DDO
D-aspartate oxidase

Protein Summary
Description
Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate. The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2019]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368923
  • ENSP00000357919
  • ENSG00000203797
  • ENST00000368924
  • ENSP00000357920

Symbol
  • DASOX
  • DDO-1
  • DDO-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.68
virus perturbation
0.59
tissue
0.54
histone modification site profile
0.52
gene perturbation
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.97   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.97   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (94)
NIT2
Tbio
Family:  Enzyme
Novelty:  0.01003111
Score:  0.962
Data Source:  STRINGDB
PAOX
Tchem
Family:  Enzyme
Novelty:  0.00905719
Score:  0.956
Data Source:  STRINGDB
HAO1
Tclin
Family:  Enzyme
Novelty:  0.00054723
Score:  0.955
Data Source:  STRINGDB
PIPOX
Tbio
Family:  Enzyme
Novelty:  0.04107707
Score:  0.951
Data Source:  STRINGDB
AGXT
Tbio
Family:  Enzyme
Novelty:  0.00267512
Score:  0.948
Data Source:  STRINGDB
CAT
Tbio
Family:  Enzyme
Novelty:  0.00181888
Score:  0.938
Data Source:  STRINGDB
IL4I1
Tbio
Family:  Enzyme
Novelty:  0.00414355
Score:  0.936
Data Source:  STRINGDB
TYSND1
Tbio
Family:  Enzyme
Novelty:  0.16036122
Score:  0.932
Data Source:  STRINGDB
HAO2
Tchem
Family:  Enzyme
Novelty:  0.03029536
Score:  0.931
Data Source:  STRINGDB
ACOX2
Tbio
Family:  Enzyme
Novelty:  0.02942359
Score:  0.925
Data Source:  STRINGDB
Pathways (9)
Glyoxylate metabolism and glycine degradation (R-HSA-389661)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Peroxisomal protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Glyoxylate metabolism and glycine degradation
Metabolism
Metabolism of amino acids and derivatives
Peroxisomal protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
4
93.8
reticulocyte measurement
3
2
3
92.7
reticulocyte count
7
2
7
92
blood metabolite measurement
2
1
8
81.7
platelet count
2
2
2
79.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
93.8
reticulocyte measurement
3
92.7
reticulocyte count
7
92
blood metabolite measurement
8
81.7
platelet count
2
79.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
D-aspartate oxidase
VGNC:2682
100608048
Mouse
MGI:1925528
70503
Rat
RGD:1595123
685325
Dog
D-aspartate oxidase
VGNC:39840
475026
Horse
D-aspartate oxidase
VGNC:17079
100072326
Species
Name
OMA
EggNOG
Inparanoid
Chimp
D-aspartate oxidase
Mouse
Rat
Dog
D-aspartate oxidase
Horse
D-aspartate oxidase
Publication Statistics
PubMed Score 42.97
PubMed score by year
PubTator Score 27.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title