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Tbio
PFDN5
Prefoldin subunit 5

Protein Classes
Protein Summary
Description
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC. This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243040
  • ENSP00000243040
  • ENSG00000123349
  • ENST00000334478
  • ENSP00000334188
  • ENST00000351500
  • ENSP00000266964
  • ENST00000551018
  • ENSP00000447942

Symbol
  • MM1
  • PFD5
  • MM1
  • MM-1
  • PFD5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
transcription factor perturbation
0.97
kinase perturbation
0.95
virus perturbation
0.88
phenotype
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.52   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 237   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.52   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (6)
Chaperonin-mediated protein folding (R-HSA-390466)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Reactome
Metabolism of proteins
Reactome
Prefoldin mediated transfer of substrate to CCT/TriC
Reactome
Protein folding
Name
Explore in Pharos
Explore in Source
Chaperonin-mediated protein folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Metabolism of proteins
Prefoldin mediated transfer of substrate to CCT/TriC
Protein folding
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (287)
1 – 10 of 287
PFDN4
Tbio
Novelty: 0.02826158
p_int: 0.999920558
p_ni: 0.000079442
Score: 0.999
Data Source: BioPlex,STRINGDB
PFDN2
Tbio
Novelty: 0.12469692
p_int: 0.999801116
p_ni: 0.000198884
Score: 0.999
Data Source: BioPlex,STRINGDB
GNB2
Tbio
Novelty: 0.20536996
p_int: 0.996168697
p_ni: 0.003831303
Score: 0.512
Data Source: BioPlex,STRINGDB
VBP1
Tbio
Novelty: 0.05609599
p_int: 0.986330474
p_ni: 0.013669526
Score: 0.999
Data Source: BioPlex,STRINGDB
KLHDC2
Tbio
Novelty: 0.02314409
p_int: 0.869911825
p_ni: 0.130088175
Score: 0.54
Data Source: BioPlex,STRINGDB
DDB2
Tbio
Novelty: 0.00809774
p_int: 0.863163528
p_ni: 0.136836472
Score: 0.741
Data Source: BioPlex,STRINGDB
PFDN1
Tbio
Novelty: 0.1113025
Score: 0.999
Data Source: STRINGDB
PFDN6
Tbio
Novelty: 0.02635016
Score: 0.999
Data Source: STRINGDB
CCT8
Tbio
Novelty: 0.03009096
Score: 0.981
Data Source: STRINGDB
CCT4
Tbio
Novelty: 0.01624952
Score: 0.966
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.52

PubMed score by year
PubTator Score  108.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer