Tbio PFDN5 Prefoldin subunit 5

Protein Summary

Description

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC. This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q99471
• A8K9A8
• Q54AA8
• Q9C083
• Q9C084

Gene Name

• PFDN5

Ensembl ID

• ENST00000243040
• ENSP00000243040
• ENSG00000123349
• ENST00000334478
• ENSP00000334188
• ENST00000351500
• ENSP00000266964
• ENST00000551018
• ENSP00000447942

Symbol

• MM1
• PFD5
• MM1
• MM-1
• PFD5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
transcription factor perturbation	0.97
kinase perturbation	0.95
virus perturbation	0.88
phenotype	0.81

Protein Classes

PANTHER Classes

Protein / Chaperone / Prefoldin Subunit 5

DTO Classes

Protein / Chaperone / Prefoldin Subunit 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.31   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 237   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.31   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0