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Tbio
PCYT2
Ethanolamine-phosphate cytidylyltransferase

Protein Summary
Description
Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine. This gene encodes an enzyme that catalyzes the formation of CDP-ethanolamine from CTP and phosphoethanolamine in the Kennedy pathway of phospholipid synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331285
  • ENSP00000331719
  • ENSG00000185813
  • ENST00000538721
  • ENSP00000442050
  • ENST00000538936
  • ENSP00000439245
  • ENST00000570388
  • ENSP00000458330
  • ENST00000570391
  • ENSP00000461190

Symbol
  • ET
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor
0.78
transcription factor binding site profile
0.64
tissue sample
0.62
small molecule perturbation
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.68   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.68   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
1
1
1
73.2
BMI-adjusted waist-hip ratio
2
3
3
58.3
BMI-adjusted hip circumference
1
2
2
55.8
birth weight
2
2
2
55.2
hematocrit
2
2
2
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
1
73.2
BMI-adjusted waist-hip ratio
3
58.3
BMI-adjusted hip circumference
2
55.8
birth weight
2
55.2
hematocrit
2
55.2
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphate cytidylyltransferase 2, ethanolamine
VGNC:9504
454974
Macaque
phosphate cytidylyltransferase 2, ethanolamine
715006
Mouse
MGI:1915921
68671
Rat
RGD:619970
89841
Dog
phosphate cytidylyltransferase 2, ethanolamine
VGNC:44331
607608
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphate cytidylyltransferase 2, ethanolamine
Macaque
phosphate cytidylyltransferase 2, ethanolamine
Mouse
Rat
Dog
phosphate cytidylyltransferase 2, ethanolamine
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99447-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PE
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PE
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (86)
1 – 10 of 86
PRKN
Tbio
Family:  Enzyme
Novelty:  0.00079898
p_int:  0.997945413
p_ni:  0.002054587
Score:  0.455
Data Source:  BioPlex,STRINGDB
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
p_int:  0.995955973
p_ni:  0.004044026
p_wrong:  1e-9
Score:  0.35
Data Source:  BioPlex,STRINGDB
RAB26
Tbio
Family:  Enzyme
Novelty:  0.12023869
p_int:  0.984629248
p_ni:  0.014272579
p_wrong:  0.001098173
Data Source:  BioPlex
CHKB
Tbio
Family:  Kinase
Novelty:  0.00862294
Score:  0.981
Data Source:  STRINGDB
CHKA
Tchem
Family:  Kinase
Novelty:  0.00237839
Score:  0.981
Data Source:  STRINGDB
CEPT1
Tchem
Family:  Enzyme
Novelty:  0.01816476
Score:  0.979
Data Source:  STRINGDB
ETNK2
Tbio
Family:  Kinase
Novelty:  0.13225627
Score:  0.975
Data Source:  STRINGDB
PISD
Tbio
Family:  Enzyme
Novelty:  0.00966227
Score:  0.974
Data Source:  STRINGDB
SELENOI
Tbio
Family:  Enzyme
Novelty:  0.00809865
Score:  0.971
Data Source:  STRINGDB
ETNK1
Tbio
Family:  Kinase
Novelty:  0.04817798
Score:  0.967
Data Source:  STRINGDB
Publication Statistics
PubMed Score  37.68

PubMed score by year
PubTator Score  12.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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