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Tbio
SEC62
Translocation protein SEC62

Protein Summary
Description
Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337002
  • ENSP00000337688
  • ENSG00000008952
  • ENST00000480708
  • ENSP00000420331

Symbol
  • TLOC1
  • HTP1
  • TP-1
  • Dtrp1
  • TLOC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.99
disease perturbation
0.87
virus perturbation
0.83
transcription factor binding site profile
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.9   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.9   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
55.2
1
1
0
1.2
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
55.2
0
1.2
30.2
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SEC62 homolog, preprotein translocation factor
VGNC:2561
744481
Macaque
SEC62 homolog, preprotein translocation factor
696989
Mouse
MGI:1916526
69276
Rat
RGD:1308862
294912
Dog
SEC62 homolog, preprotein translocation factor
609416
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SEC62 homolog, preprotein translocation factor
Macaque
SEC62 homolog, preprotein translocation factor
Mouse
Rat
Dog
SEC62 homolog, preprotein translocation factor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q99442-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (101)
1 – 10 of 101
GYPB
Tbio
Novelty:  0.00442195
p_int:  0.999697795
p_ni:  0.000302205
Score:  0.173
Data Source:  BioPlex,STRINGDB
HEATR3
Tbio
Novelty:  0.08367436
p_int:  0.98109738
p_ni:  0.01890262
Data Source:  BioPlex
TSPAN1
Tbio
Novelty:  0.01547855
p_int:  0.967004336
p_ni:  0.032995664
Data Source:  BioPlex
KCNK16
Tbio
Family:  IC
Novelty:  0.09168043
p_int:  0.935943614
p_ni:  0.064056386
Score:  0.193
Data Source:  BioPlex,STRINGDB
B4GAT1
Tbio
Family:  Enzyme
Novelty:  0.14959923
p_int:  0.915792704
p_ni:  0.084207296
Score:  0.165
Data Source:  BioPlex,STRINGDB
SEC63
Tbio
Novelty:  0.00974614
Score:  0.999
Data Source:  STRINGDB
SEC61A1
Tbio
Novelty:  0.0026034
Score:  0.998
Data Source:  STRINGDB
SEC61B
Tbio
Novelty:  0.08622222
Score:  0.997
Data Source:  STRINGDB
SEC61G
Tbio
Novelty:  0.11375671
Score:  0.993
Data Source:  STRINGDB
SEC61A2
Tdark
Novelty:  1.46395791
Score:  0.974
Data Source:  STRINGDB
Publication Statistics
PubMed Score  85.90

PubMed score by year
PubTator Score  28.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer