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Tbio
ATP6V0B
V-type proton ATPase 21 kDa proteolipid subunit

Protein Summary
Description
Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236067
  • ENSP00000236067
  • ENSG00000117410
  • ENST00000472174
  • ENSP00000431605
  • ENST00000498664
  • ENSP00000434094

Symbol
  • ATP6F
  • ATP6F
  • HATPL
  • VMA16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.98
transcription factor perturbation
0.84
transcription factor binding site profile
0.81
cell type or tissue
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.79   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.79   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
4
3
6
80.5
intelligence
4
4
2
6
76.1
cognitive function measurement
3
2
3
66.3
household income
1
2
2
60.8
age at first sexual intercourse measurement
1
1
1
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
6
80.5
intelligence
2
6
76.1
cognitive function measurement
3
66.3
household income
2
60.8
age at first sexual intercourse measurement
1
52
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V0 subunit b
VGNC:8033
100610064
Macaque
ATPase H+ transporting V0 subunit b
702243
Mouse
MGI:1890510
114143
Dog
ATPase H+ transporting V0 subunit b
VGNC:38271
482528
Horse
ATPase H+ transporting V0 subunit b
VGNC:15670
100146553
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V0 subunit b
Macaque
ATPase H+ transporting V0 subunit b
Mouse
Dog
ATPase H+ transporting V0 subunit b
Horse
ATPase H+ transporting V0 subunit b
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q99437-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (21)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Insulin receptor recycling
Reactome
Ion channel transport
Reactome
Iron uptake and transport
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Insulin receptor recycling
Ion channel transport
Iron uptake and transport
Protein-Protein Interactions (91)
1 – 10 of 91
ATP6V1F
Tbio
Family:  Enzyme
Novelty:  0.07109314
Score:  0.997
Data Source:  STRINGDB
ATP6V0D1
Tbio
Family:  Enzyme
Novelty:  0.05146108
Score:  0.997
Data Source:  STRINGDB
ATP6V1A
Tbio
Family:  Enzyme
Novelty:  0.00921474
Score:  0.996
Data Source:  STRINGDB
ATP6V1D
Tbio
Family:  Enzyme
Novelty:  0.02298626
Score:  0.996
Data Source:  STRINGDB
ATP6V0D2
Tbio
Family:  Enzyme
Novelty:  0.0354396
Score:  0.995
Data Source:  STRINGDB
ATP6V1H
Tbio
Family:  Enzyme
Novelty:  0.04269105
Score:  0.994
Data Source:  STRINGDB
ATP6V0C
Tbio
Family:  Enzyme
Novelty:  0.01142874
Score:  0.992
Data Source:  STRINGDB
ATP6V1B2
Tchem
Family:  Enzyme
Novelty:  0.01767911
Score:  0.991
Data Source:  STRINGDB
ATP6V1C1
Tbio
Family:  Enzyme
Novelty:  0.03660846
Score:  0.99
Data Source:  STRINGDB
ATP6V0A1
Tbio
Family:  Enzyme
Novelty:  0.02009317
Score:  0.99
Data Source:  STRINGDB
Publication Statistics
PubMed Score  14.79

PubMed score by year
PubTator Score  4.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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