NELL2
Protein kinase C-binding protein NELL2
Protein Summary
Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity). The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the cytoplasm. Several variants encoding a few different isoforms exist, and at least one isoform appears to be a secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and differentiation as well as in oncogenesis. [provided by RefSeq, Feb 2009]
- ENST00000333837
- ENSP00000327988
- ENSG00000184613
- ENST00000395487
- ENSP00000378866
- ENST00000429094
- ENSP00000390680
- ENST00000437801
- ENSP00000416341
- ENST00000452445
- ENSP00000394612
- ENST00000549027
- ENSP00000447927
- NRP2
- NRP2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
PubMedID | 0.8 | ||
gene perturbation | 0.79 | ||
small molecule perturbation | 0.76 | ||
transcription factor | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.01 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 179 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.01 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 179 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0