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Tbio
NELL2
Protein kinase C-binding protein NELL2

Protein Summary
Description
Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity). The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the cytoplasm. Several variants encoding a few different isoforms exist, and at least one isoform appears to be a secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and differentiation as well as in oncogenesis. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333837
  • ENSP00000327988
  • ENSG00000184613
  • ENST00000395487
  • ENSP00000378866
  • ENST00000429094
  • ENSP00000390680
  • ENST00000437801
  • ENSP00000416341
  • ENST00000452445
  • ENSP00000394612
  • ENST00000549027
  • ENSP00000447927

Symbol
  • NRP2
  • NRP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
PubMedID
0.8
gene perturbation
0.79
small molecule perturbation
0.76
transcription factor
0.67


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.53   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.53   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
neural EGFL like 2
703134
Mouse
MGI:1858510
54003
Rat
RGD:620999
81734
Dog
neural EGFL like 2
VGNC:43740
477636
Horse
neural EGFL like 2
VGNC:20681
100054944
Species
Name
OMA
EggNOG
Inparanoid
Macaque
neural EGFL like 2
Mouse
Rat
Dog
neural EGFL like 2
Horse
neural EGFL like 2
Pathways (4)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Regulation of commissural axon pathfinding by SLIT and ROBO
Reactome
Signaling by ROBO receptors
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Regulation of commissural axon pathfinding by SLIT and ROBO
Signaling by ROBO receptors
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (53)
1 – 10 of 53
EMILIN2
Tbio
Novelty: 0.2816786
p_int: 0.999998838
p_ni: 0.000001157
p_wrong: 5e-9
Score: 0.185
Data Source: BioPlex,STRINGDB
ZBTB40
Tbio
Family: TF
Novelty: 0.17413605
p_int: 0.999962696
p_ni: 0.000037284
p_wrong: 2e-8
Score: 0.155
Data Source: BioPlex,STRINGDB
ZNF101
Tdark
Family: TF
Novelty: 0.27004566
p_int: 0.999951603
p_ni: 0.000047917
p_wrong: 4.8e-7
Score: 0.204
Data Source: BioPlex,STRINGDB
ZBTB9
Tdark
Novelty: 0.95590016
p_int: 0.999929503
p_ni: 0.000070081
p_wrong: 4.16e-7
Score: 0.229
Data Source: BioPlex,STRINGDB
POC1A
Tbio
Novelty: 0.03897985
p_int: 0.999882649
p_ni: 0.000117351
Data Source: BioPlex
PAX3
Tbio
Family: TF
Novelty: 0.00140464
p_int: 0.999858175
p_ni: 0.000003908
p_wrong: 0.000137917
Score: 0.237
Data Source: BioPlex,STRINGDB
CEP44
Tdark
Novelty: 1.20621472
p_int: 0.999822471
p_ni: 0.000177528
p_wrong: 1e-9
Data Source: BioPlex
MATN2
Tbio
Novelty: 0.08506252
p_int: 0.999811684
p_ni: 0.000181364
p_wrong: 0.000006953
Score: 0.244
Data Source: BioPlex,STRINGDB
ZNF627
Tdark
Family: TF
Novelty: 0.34605017
p_int: 0.999727401
p_ni: 0.00015842
p_wrong: 0.000114179
Score: 0.206
Data Source: BioPlex,STRINGDB
C4orf48
Tdark
Novelty: 0.57791774
p_int: 0.998755473
p_ni: 0.001244527
Score: 0.219
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  35.53

PubMed score by year
PubTator Score  17.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer