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Tbio
TBCB
Tubulin-folding cofactor B

Protein Summary
Description
Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221855
  • ENSP00000221855
  • ENSG00000105254
  • ENST00000585746
  • ENSP00000467487

Symbol
  • CG22
  • CKAP1
  • CG22
  • CKAP1
  • CKAPI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.99
histone modification site profile
0.89
virus perturbation
0.79
disease perturbation
0.74


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.31   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.31   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.914658059
p_ni:  0.085341941
Score:  0.963
Data Source:  BioPlex,STRINGDB
TBCD
Tbio
Novelty:  0.01161221
Score:  0.992
Data Source:  STRINGDB
TBCE
Tbio
Novelty:  0.01058281
Score:  0.99
Data Source:  Reactome,STRINGDB
TUBA1A
Tchem
Novelty:  0.01030145
Score:  0.959
Data Source:  STRINGDB
TUBA1B
Tchem
Novelty:  0.02465964
Score:  0.955
Data Source:  STRINGDB
TUBB4B
Tclin
Novelty:  0.04120134
Score:  0.951
Data Source:  STRINGDB
TUBA1C
Tchem
Novelty:  0.02804632
Score:  0.949
Data Source:  STRINGDB
TUBB2B
Tclin
Novelty:  0.02905844
Score:  0.947
Data Source:  STRINGDB
TUBA3E
Tchem
Novelty:  1.70475533
Score:  0.943
Data Source:  STRINGDB
TUBAL3
Tdark
Novelty:  1.0330894
Score:  0.94
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-chaperonin tubulin folding pathway
Reactome
Protein folding
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-chaperonin tubulin folding pathway
Protein folding
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
21.5
neutrophil percentage of leukocytes
1
1
1
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
21.5
neutrophil percentage of leukocytes
1
3.4
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubulin folding cofactor B
VGNC:2234
455974
Macaque
tubulin folding cofactor B
712355
Mouse
MGI:1913661
66411
Dog
tubulin folding cofactor B
VGNC:53996
476475
Horse
tubulin folding cofactor B
VGNC:23916
100060417
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubulin folding cofactor B
Macaque
tubulin folding cofactor B
Mouse
Dog
tubulin folding cofactor B
Horse
tubulin folding cofactor B
Publication Statistics
PubMed Score 36.31
PubMed score by year
PubTator Score 11.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title