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Tbio
MYCBP
c-Myc-binding protein

Protein Summary
Description
May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC. The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397572
  • ENSP00000380702
  • ENSG00000214114

Symbol
  • AMY1
  • AMY-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
transcription factor perturbation
0.8
microRNA
0.79
virus perturbation
0.76
small molecule perturbation
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.87   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.87   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
PDGF signaling pathway
PathwayCommons: pid
Notch signaling pathway
Name
Explore in Pharos
Explore in Source
PDGF signaling pathway
Notch signaling pathway
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (27)
1 – 10 of 27
OTUD4
Tbio
Novelty: 0.17121119
p_int: 0.999999965
p_ni: 3.5e-8
Data Source: BioPlex
ARFGEF2
Tbio
Novelty: 0.05568966
p_int: 0.999989842
p_ni: 0.000010158
Score: 0.402
Data Source: BioPlex,STRINGDB
SPAG5
Tbio
Novelty: 0.02392116
p_int: 0.999957012
p_ni: 0.000042988
Data Source: BioPlex
KNSTRN
Tbio
Novelty: 0.05283444
p_int: 0.999898033
p_ni: 0.000101208
p_wrong: 7.59e-7
Score: 0.43
Data Source: BioPlex,STRINGDB
ARFGEF1
Tbio
Novelty: 0.16148196
p_int: 0.999411805
p_ni: 0.000588195
Score: 0.51
Data Source: BioPlex,STRINGDB
SELENOO
Tdark
Novelty: 0.02959704
p_int: 0.999279532
p_ni: 0.000371453
p_wrong: 0.000349015
Data Source: BioPlex
HEXIM2
Tbio
Novelty: 0.14814693
p_int: 0.996825072
p_ni: 0.003174927
p_wrong: 2e-9
Score: 0.282
Data Source: BioPlex,STRINGDB
ALG13
Tbio
Family: Enzyme
Novelty: 0.04054611
p_int: 0.996726565
p_ni: 0.003273434
Data Source: BioPlex
AKAP8
Tbio
Family: Enzyme
Novelty: 0.03447626
p_int: 0.777506448
p_ni: 0.222493552
Score: 0.679
Data Source: BioPlex,STRINGDB
MAATS1
Tbio
Novelty: 0.17802223
Score: 0.983
Data Source: STRINGDB
Publication Statistics
PubMed Score  21.87

PubMed score by year
PubTator Score  16.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer