Protein Summary
May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelial cells segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. The major constituents of mucus, the viscous secretion that covers epithelial ...more
- ENST00000346145
- ENSP00000304207
- ENSG00000145113
- ENST00000349607
- ENSP00000338109
- ASGP
- MUC-4
- HSA276359
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.87 | ||
cellular component | 0.74 | ||
cell line | 0.67 | ||
PubMedID | 0.61 | ||
tissue sample | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 576.63 (req: < 5)
Gene RIFs: 145 (req: <= 3)
Antibodies: 323 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 576.63 (req: >= 5)
Gene RIFs: 145 (req: > 3)
Antibodies: 323 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (120)
Nearest Tclin Targets
Pathways (15)
Reactome (15)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | C-type lectin receptors (CLRs) | ||||
Reactome | Dectin-2 family | ||||
Reactome | Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) | ||||
Reactome | Defective GALNT12 causes colorectal cancer 1 (CRCS1) | ||||
Reactome | Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
C-type lectin receptors (CLRs) | ||||
Dectin-2 family | ||||
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) | ||||
Defective GALNT12 causes colorectal cancer 1 (CRCS1) | ||||
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (2)
Components (8)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glomerular filtration rate | 2 | 2 | 1 | 5.6 | 55.8 | ||||
lung disease associated with cystic fibrosis | 1 | 1 | 1 | 48.5 | |||||
creatinine measurement | 1 | 1 | 1 | 48.5 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glomerular filtration rate | 1 | 5.6 | 55.8 | ||||
lung disease associated with cystic fibrosis | 1 | 48.5 | |||||
creatinine measurement | 1 | 48.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:2153525 | 140474 | ||||||
Rat | RGD:621331 | 303887 | ||||||
Pig | mucin 4, cell surface associated | 100157344 | ||||||
Xenopus | mucin 4, cell surface associated | XB-GENE-852599 | 100485162 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Pig | mucin 4, cell surface associated | |||||
Xenopus | mucin 4, cell surface associated | |||||
Publication Statistics
PubMed Score 576.63
PubMed score by year
PubTator Score 329.74
PubTator score by year
Related Publications
Text Mined References (165)
GeneRif Annotations (145)
Items per page:
0 of 0
PMID | Year | Title |
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