Tbio MUC4 Mucin-4

Protein Summary

Description

May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelial cells segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q99102
• O95938
• Q9GZM2
• Q9GZV6
• Q9H481
• Q9H482
• Q9H483
• Q9H484
• Q9H485
• Q9H486
• Q9H487
• Q9H4D6
• Q9H4D8
• Q9NPJ0
• Q9NY09
• Q9NY75
• Q9NY76
• Q9NY77
• Q9NY78
• Q9NY79
• Q9NY80
• Q9NY81
• MUC-4

Gene Name

• MUC4

Ensembl ID

• ENST00000346145
• ENSP00000304207
• ENSG00000145113
• ENST00000349607
• ENSP00000338109

Symbol

• ASGP
• MUC-4
• HSA276359

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.87
cellular component	0.74
cell line	0.67
PubMedID	0.61
tissue sample	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 644.29   (req: < 5)

Gene RIFs: 175   (req: <= 3)

Antibodies: 323   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 644.29   (req: >= 5)

Gene RIFs: 175   (req: > 3)

Antibodies: 323   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0